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Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic HepatitisTatsumi C.a · Kudo M.a · Ueshima K.a · Kitai S.a · Ishikawa E.a · Yada N.a · Hagiwara S.a · Inoue T.a · Minami Y.a · Chung H.a · Maekawa K.b · Fujimoto K.c · Kato M.c · Tonomura A.d · Mitake T.d · Shiina T.e
aDepartment of Gastroenterology and Hepatology, Kinki University School of Medicine, and bDivision of Abdominal Ultrasound, Department of Laboratory Medicine, Kinki University School of Medicine, Osaka-Sayama, cDepartment of Internal Medicine, National Hospital Organization Minami-Wakayama Medical Center, Tanabe, dHitachi Medical Corporation, Tokyo, and eHuman Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan Corresponding Author
Masatoshi Kudo, MD, PhD, Division of Gastroenterology and Hepatology
Department of Internal Medicine, Kinki University School of Medicine
377-2, Ohno-Higashi, Osaka-Sayama 589-8511 (Japan)
Tel. +81 72 366 0221, ext. 3149, Fax +81 72 367 2880
Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.
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