Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function is known, selenocysteine is located at the active center. The presence of selenocysteine at critical sites in naturally occurring selenoproteins provides an explanation for the important role of selenium in human health and development. This review describes known mammalian selenoproteins and discusses recent developments and future directions in the selenium field.
Received: Received: November 25, 1998
Accepted: November 25, 1998
Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 1, Number of References : 104
Journal of Biomedical Science (Sponsored by the National Science Council, Taipei)
Vol. 6, No. 3, Year 1999 (Cover Date: May-June 1999)
Journal Editor: Chuan C. Chang, Taipei
ISSN: 1021–7770 (print), 1423–0127 (Online)
For additional information: http://www.karger.com/journals/jbs
Article / Publication Details
Published online: 5/12/1999
Issue release date: May–June 1999
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1
ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)
For additional information: http://www.karger.com/JBS
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