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Vol. 6, No. 3, 1999
Issue release date: May–June 1999
Section title: Review
J Biomed Sci 1999;6:151–160
(DOI:10.1159/000025383)

Selenocysteine-Containing Proteins in Mammals

Gladyshev V.N. · Hatfield D.L.
aDepartment of Biochemistry, University of Nebraska, Lincoln, Nebr., and bSection on the Molecular Biology of Selenium, Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 5/12/1999

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS

Abstract

Since the recent discovery of selenocysteine as the 21st amino acid in protein, the field of selenium biology has rapidly expanded. Twelve mammalian selenoproteins have been characterized to date and each contains selenocysteine that is incorporated in response to specific UGA code words. These selenoproteins have different cellular functions, but in those selenoproteins for which the function is known, selenocysteine is located at the active center. The presence of selenocysteine at critical sites in naturally occurring selenoproteins provides an explanation for the important role of selenium in human health and development. This review describes known mammalian selenoproteins and discusses recent developments and future directions in the selenium field.


  

Author Contacts

Dr. Vadim N. Gladyshev
Department of Biochemistry, University of Nebraska
Lincoln, NE 68588 (USA)
Tel. +1 402 472 4948, Fax +1 402 472 7842
E-Mail vng@unlinfo2.unl.edu

  

Article Information

Received: Received: November 25, 1998
Accepted: November 25, 1998
Number of Print Pages : 10
Number of Figures : 0, Number of Tables : 1, Number of References : 104

  

Publication Details

Journal of Biomedical Science (Sponsored by the National Science Council, Taipei)

Vol. 6, No. 3, Year 1999 (Cover Date: May-June 1999)

Journal Editor: Chuan C. Chang, Taipei
ISSN: 1021–7770 (print), 1423–0127 (Online)

For additional information: http://www.karger.com/journals/jbs


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 5/12/1999

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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