Journal Mobile Options
Table of Contents
Vol. 1, No. 1, 2009
Issue release date: January – December
Open Access Gateway
Case Rep Dermatol 2009;1:87–92
(DOI:10.1159/000253874)
Published: November 2009

Primary Cutaneous Large B-Cell Lymphoma, Leg Type, Localized on the Dorsum

Patrizi A.a · Raone B.a · Sabattini E.b · Gurioli C.a · Pileri Jr. A.a · D’Acunto C.a
aDermatology, Department of Internal Medicine, Geriatrics and Nephrologic Diseases, and bHemolymphopathology Unit, Institute of Hematology and Clinical Oncology ‘L.A. Seragnoli’, University of Bologna, Bologna, Italy

Abstract

Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT), is a large B-cell lymphoma primarily involving the skin. It is distinguished from the other 3 subsets of this lymphoproliferative disorder by its immunohistopathological features, configuring confluent sheets of medium-sized to large B lymphocytes with round nuclei provided with evident nucleoli, resembling centroblasts or immunoblasts, which express Bcl-6, Bcl-2. Prevalently appearing on the lower limbs, as a single or multicentric and frequently ulcerated skin nodule or plaque, PCLBCL-LT has a worse prognosis than the other large B-cell lymphomas. Moreover, the age of onset is delayed (7th decade) compared to those of the other 3 subtypes (6th decade); it presents a slight female predominance (2:1), and a higher percentage of positivity to Bcl-2. We present a 52-year-old man who showed a 2-year standing, non-ulcerated, round, 4 cm in diameter, red plaque, medially located on the dorsum. After biopsy the diagnosis of PCLBCL-LT was made on histopathological and immunohistochemical studies, the latter showing positivity to CD20, Bcl-2, and Bcl-6. After treatment with radiotherapy the patient has shown a 4.4-year follow-up free of disease.

 goto top of outline Author Contacts

Prof. Annalisa Patrizi
Policlinico S. Orsola-Malpighi
Via G. Massarenti 1
IT–40138 Bologna (Italy)
Tel. +39 051 636 4847, Fax +39 051 347 847, E-Mail annalisa.patrizi@unibo.it


 goto top of outline Article Information

Published online: November 11, 2009
Number of Print Pages : 6
Number of Figures : 3,


 goto top of outline Publication Details

Case Reports in Dermatology

Vol. 1, No. 1, Year 2009 (Cover Date: January - December)

Journal Editor: Jemec G. (Roskilde)
ISSN: NIL (Print), eISSN: 1662-6567 (Online)

For additional information: http://www.karger.com/CDE


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.