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Primary Cutaneous Large B-Cell Lymphoma, Leg Type, Localized on the DorsumPatrizi A.a · Raone B.a · Sabattini E.b · Gurioli C.a · Pileri Jr. A.a · D’Acunto C.a
aDermatology, Department of Internal Medicine, Geriatrics and Nephrologic Diseases, and bHemolymphopathology Unit, Institute of Hematology and Clinical Oncology ‘L.A. Seragnoli’, University of Bologna, Bologna, Italy Corresponding Author
Prof. Annalisa Patrizi
Policlinico S. Orsola-Malpighi
Via G. Massarenti 1
IT–40138 Bologna (Italy)
Tel. +39 051 636 4847, Fax +39 051 347 847, E-Mail email@example.com
Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT), is a large B-cell lymphoma primarily involving the skin. It is distinguished from the other 3 subsets of this lymphoproliferative disorder by its immunohistopathological features, configuring confluent sheets of medium-sized to large B lymphocytes with round nuclei provided with evident nucleoli, resembling centroblasts or immunoblasts, which express Bcl-6, Bcl-2. Prevalently appearing on the lower limbs, as a single or multicentric and frequently ulcerated skin nodule or plaque, PCLBCL-LT has a worse prognosis than the other large B-cell lymphomas. Moreover, the age of onset is delayed (7th decade) compared to those of the other 3 subtypes (6th decade); it presents a slight female predominance (2:1), and a higher percentage of positivity to Bcl-2. We present a 52-year-old man who showed a 2-year standing, non-ulcerated, round, 4 cm in diameter, red plaque, medially located on the dorsum. After biopsy the diagnosis of PCLBCL-LT was made on histopathological and immunohistochemical studies, the latter showing positivity to CD20, Bcl-2, and Bcl-6. After treatment with radiotherapy the patient has shown a 4.4-year follow-up free of disease.
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