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Vol. 114, No. 2, 2010
Issue release date: February 2010
Section title: Original Paper
Nephron Clin Pract 2010;114:c108–c117
(DOI:10.1159/000254383)

Suitability of the IDMS-Traceable MDRD Equation Method to Estimate GFR in Early Postoperative Renal Transplant Recipients

Yeo Y.a · Han D.-J.b · Moon D.H.c · Park J.S.a · Yang W.S.a · Chang J.W.a · Byun S.W.a · Park S.-K.a
aDivision of Nephrology, Department of Internal Medicine, bDepartment of Surgery and cDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/12/2009
Accepted: 6/2/2009
Published online: 11/3/2009
Issue release date: February 2010

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 5

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background/Aims: Accurate measurement of glomerular filtration rate (GFR) is critical for the management of kidney transplant recipients. Comparison of creatinine and cystatin C in renal transplant recipients gave conflicting results. We aimed to compare the performance of creatinine- and cystatin C-based equations and creatinine clearance in 102 early postoperative Korean renal transplant patients. Methods: We measured 51Cr-EDTA clearance using a 2-compartment model and considered this the reference GFR. Then, we estimated GFR using 13 creatinine- and 7 cystatin C-based equations. Serum creatinine value was calibrated to isotope-dilution mass spectrometry (IDMS). Results: The mean reference GFR was 76.77 ± 17.01 ml/min/1.73 m2. The IDMS-traceable MDRD (IDMS-MDRD) equation had the highest accuracy (94.12 within 30% of the reference; 99.02 within 50% of the reference) with a bias of 0.33 ml/min/1.73 m2 and a precision of 12.57 ml/min/1.73 m2. The Mayo Clinic equation also performed well (92.16% within 30% of the reference; 99.02% within 50% of the reference; bias: –0.19 ml/min/1.73 m2). As for cystatin C-based equations, the Filler equation had the least bias (0.03 ml/min/1.73 m2) but low accuracy (78.43% within 30% of the reference). Conclusions: We conclude that the IDMS-MDRD equation provided the best estimate of GFR in our early postoperative Korean renal transplant patients.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/12/2009
Accepted: 6/2/2009
Published online: 11/3/2009
Issue release date: February 2010

Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 5

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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