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Table of Contents
Vol. 7, No. 6, 2000
Issue release date: November–December 2000
Section title: Review
J Biomed Sci 2000;7:444–458
(DOI:10.1159/000025480)

Actions of Melatonin in the Reduction of Oxidative Stress

A Review

Reiter R.J. · Tan D.-X. · Osuna C. · Gitto E.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Tex., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 11/9/2000
Issue release date: November–December 2000

Number of Print Pages: 15
Number of Figures: 5
Number of Tables: 1

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS

Abstract

Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Additionally, melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. The following antioxidative enzymes are also stimulated by melatonin: superoxide dismutase, glutathione peroxidase and glutathione reductase. Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms.

© 2000 National Science Council, ROC and S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 11/9/2000
Issue release date: November–December 2000

Number of Print Pages: 15
Number of Figures: 5
Number of Tables: 1

ISSN: 1021-7770 (Print)
eISSN: 1423-0127 (Online)

For additional information: http://www.karger.com/JBS


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