Vascular communication of vasomotor signals appears to coordinate the distribution of tissue blood flow. This study was performed to determine whether elevated tissue concentrations of adenosine or nitric oxide could induce vascular communicating signals. To test this, remote arteriolar responses were tested when drugs were applied either directly to an arteriole (∼20 μm diameter), or into the tissue in a region (with no vessels over 10 μm in diameter) that was 500 μm away from the arteriole and that bore no defined relationship to the flow path of the remote arteriole. In anesthetized hamster cheek pouch (n = 25), or cremaster muscle (n = 10), remote arteriolar responses were measured in response to nitric oxide (NO) donors (10–5 to 10–3 M), adenosine (10–5 to 10–3 M), or papaverine (10–5 to 10–2 M) applied for 40–120 s. Papaverine caused no remote response when applied directly while adenosine and NO donors caused similar, late-onset (10–20 s), dose-dependent, remote responses in both preparations. Remarkably however, only adenosine initiated a consistent remote arteriolar dilation when applied to the tissue site. Thus, increases in tissue adenosine may be critical for vascular communication of metabolic demands without regard to the specific blood flow path.
Dr. Richard Rivers
Department of Anesthesiology
601 Elmwood Ave., Box 604
Rochester, NY 14642 (USA)
Fax +1 716 273 2397, E-Mail firstname.lastname@example.org
Received: Received: November 2, 1998
Accepted after revision: February 3, 1999
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 1, Number of References : 23
Journal of Vascular Research
Founded 1964 as Angiologica by M. Comèl and L. Laszt (1964–1973) continued as Blood Vessels by J.A. Bevan (1974–1991)
Vol. 36, No. 3, Year 1999 (Cover Date: May-June 1999)
Journal Editor: M.J. Mulvany, Aarhus
ISSN: 1018–1172 (print), 1423–0135 (Online)
For additional information: http://www.karger.com/journals/jvr
Article / Publication Details
Published online: 6/18/1999
Issue release date: May–June 1999
Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 1
ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)
For additional information: http://www.karger.com/JVR
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