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Vol. 36, No. 4, 1999
Issue release date: July–August 1999
Section title: Research Paper
J Vasc Res 1999;36:282–288
(DOI:10.1159/000025656)

Leukocyte Margination in Alveolar Capillaries: Interrelationship with Functional Capillary Geometry and Microhemodynamics

Kuebler W.M. · Kuhnle G.E.H. · Goetz A.E.
aInstitute for Surgical Research and bDepartment of Anesthesiology, University of Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: 8/27/1999

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

The pulmonary capillary microvasculature harbors a large pool of intravascularly marginated leukocytes. In this study, we investigated the interrelationship of leukocyte margination with characteristics of functional capillary geometry and microhemodynamics in alveolar capillary networks. In 22 anesthetized rabbits we assessed functional capillary density, average capillary length, red blood cell velocity and leukocyte kinetics in alveolar capillary networks in vivo by intravital fluorescence microscopy. In alveolar wall areas of 12,800 ± 1,800 μm2, we detected 3.6 ± 0.5 sticking leukocytes and 21.0 ± 1.9 functional capillary segments with an average capillary length of 35.7 ± 2.1 μm. We calculated that approximately 15% of functional capillary segments are blocked by marginated leukocytes. Leukocyte margination was predominantly observed in capillary networks characterized by a high functional capillary density, short capillary segments and low red blood cell velocities. The multitude of interconnected capillary channels in these networks may allow alveolar blood flow to bypass marginated leukocytes. Hence, this interrelationship may be relevant for maintenance of adequate alveolar perfusion and low capillary network resistance despite excessive leukocyte margination in the pulmonary microvasculature. Local microhemodynamic factors may play a regulatory role in the spatial distribution of leukocyte margination.


  

Author Contacts

Dr. Wolfgang M. Kuebler
Institute for Surgical Research, University of Munich
Marchioninistrasse 15
D–81366 Munich (Germany)
Tel. +49 89 7095 4356, Fax +49 89 7095 8897, E-Mail wk80@columbia.edu

  

Article Information

Received: Received: June 29, 1998
Accepted after revision: March 15, 1999
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 24

  

Publication Details

Journal of Vascular Research
Founded 1964 as Angiologica by M. Comèl and L. Laszt (1964–1973) continued as Blood Vessels by J.A. Bevan (1974–1991)

Vol. 36, No. 4, Year 1999 (Cover Date: July-August 1999)

Journal Editor: M.J. Mulvany, Aarhus
ISSN: 1018–1172 (print), 1423–0135 (Online)

For additional information: http://www.karger.com/journals/jvr


Article / Publication Details

First-Page Preview
Abstract of Research Paper

Published online: 8/27/1999

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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