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Vol. 28, No. 5, 2009
Issue release date: December 2009
Section title: Original Research Article
Dement Geriatr Cogn Disord 2009;28:476–485
(DOI:10.1159/000258100)

Patterns of Cortical Thickness according to APOE Genotype in Alzheimer’s Disease

Gutiérrez-Galve L. · Lehmann M. · Hobbs N.Z. · Clarkson M.J. · Ridgway G.R. · Crutch S. · Ourselin S. · Schott J.M. · Fox N.C. · Barnes J.
aDementia Research Centre, Institute of Neurology, and bCentre for Medical Image Computing (CMIC), University College London (UCL), London, UK; cCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spanish Ministry of Health, Madrid, and dInstituto Aragonés de Ciencias de la Salud, Zaragoza, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 9/22/2009
Published online: 11/26/2009

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: Possession of one or more apolipoprotein E (APOE) ε4 alleles may influence the distribution of atrophy and clinical phenotype. We aimed to assess the influence of APOE genotype on cortical thickness and regional brain volumes in AD (Alzheimer’s disease). Methods: We included 38 patients (9 ε4 non-carriers, 23 ε4 heterozygotes, 6 ε4 homozygotes) and 23 controls. Each subject had 2 magnetic resonance imaging (MRI) scans and a neuropsychological battery. Cortical thickness and isthmus cingulate volume were measured using FreeSurfer; the volumes of the hippocampus, whole brain, and lateral ventricles were calculated using manual and semi-automated volumetry. Results: Compared with controls, cortical thickness was significantly lower: in the bilateral temporal, posterior parietal and occipital regions in non-carriers, in the medial temporal and left parietal regions in heterozygotes, and in the medial temporal lobe in homozygotes. Comparisons between AD subgroups did not show significant differences. A trend for larger brain and isthmus cingulate volumes and smaller hippocampal and ventricular volumes with increasing ε4 dose were seen. These differences were supported by neuropsychological profiles. Conclusion: These results suggest that APOE genotype may influence the topography of regional atrophy and cortical thinning in AD.


  

Author Contacts

Dr. Josephine Barnes
Dementia Research Centre, Institute of Neurology, University College London (UCL)
Queen Square, London WC1N 3BG (UK)
Tel. +44 8451 555 000, Fax +44 207 676 2066
E-Mail j.barnes@dementia.ion.ucl.ac.uk

  

Article Information

Accepted: September 22, 2009
Published online: November 26, 2009
Number of Print Pages : 10
Number of Figures : 2, Number of Tables : 3, Number of References : 58
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 28, No. 5, Year 2009 (Cover Date: December 2009)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 9/22/2009
Published online: 11/26/2009

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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