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Vol. 55, No. 4, 2009
Issue release date: December 2009
Section title: Original Paper
Ann Nutr Metab 2009;55:368–374
(DOI:10.1159/000258633)

A Meta-Analysis Evaluating the Impact of Chitosan on Serum Lipids in Hypercholesterolemic Patients

Baker W.L. · Tercius A. · Anglade M. · White C.M. · Coleman C.I.
University of Connecticut Schools of aPharmacy and bMedicine, Storrs, Conn. and Farmington, Conn., and cEvidence-Based Practice Center at Hartford Hospital, Hartford, Conn., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/17/2008
Accepted: 9/7/2009
Published online: 11/13/2009
Issue release date: December 2009

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Objective: Chitosan is increasingly being used in the United States as an over-the-counter cholesterol-lowering agent. The positively charged amino groups of chitosan may have the ability to bind negatively charged molecules such as lipids and bile acids, inducing a greater fractional excretion in the feces. To better characterize the impact of chitosan on serum lipids in hypercholesterolemic patients, we performed a meta-analysis of randomized controlled trials. Methods: A systematic literature search of Medline, Embase, Cochrane Central and the Natural Medicines Comprehensive Database was conducted from the earliest possible date through May 2008. Trials were included in the analysis if they were randomized, placebo-controlled trials of chitosan in hypercholesterolemic patients and reported efficacy data on total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol or triglycerides. The weighted mean difference (WMD) of the change from baseline (in milligrams per deciliter) with 95% confidence interval was calculated as the difference between the mean in the chitosan and placebo groups using a random-effects model. Results: Six studies (n = 416 patients) met the inclusion criteria. Upon meta-analysis, the use of chitosan significantly lowered total cholesterol [WMD, –11.59 mg/dl (–21.45 to –1.73), p = 0.02] but not LDL cholesterol, HDL cholesterol or triglycerides. Conclusions: Based upon the currently available literature, we can only say that chitosan beneficially affects total cholesterol with 95% confidence. Additional, larger randomized controlled trials are needed to better characterize the effect of chitosan on other lipoproteins.


  

Author Contacts

Craig I. Coleman, PharmD
Associate Professor of Pharmacy Practice
University of Connecticut/Hartford Hospital Evidence-Based Practice Center
Hartford Hospital, 80 Seymour Street, Hartford, CT 06102-5037 (USA)
Tel. +1 860 545 2096, Fax +1 860 545 2277, E-Mail ccolema@harthosp.org

  

Article Information

Received: November 17, 2008
Accepted after revision: September 7, 2009
Published online: November 13, 2009
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 1, Number of References : 21

  

Publication Details

Annals of Nutrition and Metabolism (Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 55, No. 4, Year 2009 (Cover Date: December 2009)

Journal Editor: Elmadfa I. (Vienna)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/17/2008
Accepted: 9/7/2009
Published online: 11/13/2009
Issue release date: December 2009

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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