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Table of Contents
Vol. 3, No. 1, 1997
Issue release date: 1997
Section title: Research Report
Eur Addict Res 1997;3:49–54
(DOI:10.1159/000259147)

Behavioral and Cardiovascular Effects of Intravenous Methylphenidate in Normal Subjects and Cocaine Abusers

Wang G.-J.a,b · Volkow N.D.a,c · Hitzemann R.J.c,d · Wong C.a · Angrist B.e · Burr G.d · Pascani K.d · Pappas N.a · Lu A.a · Cooper T.e · Lieberman J.A.f
aMedical Department, Brookhaven National Laboratory, Upton, N.Y.; Departments of bRadiology (GJW) and cPsychiatry, SUNY, Stony Brook, N.Y., dDepartment of Psychiatry, VA Medical Center, Northport, N.Y., eDepartment of Psychiatry, New York University, New York, NY., fDepartment of Psychiatry, Long Island Jewish Medical Center, Albert Einstein College of Medicine, Glen Oaks, NY., USA

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Article / Publication Details

First-Page Preview
Abstract of Research Report

Published online: 11/11/2009
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1022-6877 (Print)
eISSN: 1421-9891 (Online)

For additional information: http://www.karger.com/EAR

Abstract

This study compares the behavioral and cardiovascular response to methylphenidate (0.5 mg i.v.) in 10 cocaine abusers and 20 controls. Methylphenidate induced a long-lasting increase in blood pressure and pulse rate in both groups of subjects. It also induced a short-lasting ‘high’ (27 min) and longer-lasting ‘restlessness’ (67 min). In the normal subjects, but not in the cocaine abusers, methylphenidate significantly increased sexual desire and induced a subjective experience of ‘loss of control’. In the cocaine abusers, methylphenidate consistently induced cocaine craving. While 90% of the cocaine abusers reported methylphenidate as pleasurable, only 50% of the normal subjects did. Cocaine abusers reported that the ‘high’ induced by methylphenidate was similar to that of cocaine but lasted longer and was associated with more physical effects.

© 1997 S. Karger AG, Basel


  

Author Contacts

Gene-Jack Wang, MD, Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (USA)

  

Article Information

Published online: November 11, 2009
Number of Print Pages : 6

  

Publication Details

European Addiction Research

Vol. 3, No. 1, Year 1997 (Cover Date: 1997)

Journal Editor: van den Brink W. (Amsterdam), Haasen C. (Hamburg)
ISSN: 1022-6877 (Print), eISSN: 1421-9891 (Online)

For additional information: http://www.karger.com/EAR


Article / Publication Details

First-Page Preview
Abstract of Research Report

Published online: 11/11/2009
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1022-6877 (Print)
eISSN: 1421-9891 (Online)

For additional information: http://www.karger.com/EAR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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