Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the DiagnosisBehling K.C. · Foster D.M.J. · Edmonston T.B. · Witkiewicz A.K.
Department of Pathology, Thomas Jefferson University, Philadelphia, Pa., USA
Mycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has also been documented in the gastrointestinal tract of solid organ transplant patients. Because the treatment for these two entities is different, i.e. removal of the offending agent versus the administration of steroids, proper identification of the cause is imperative. We present a case of mycophenolate mofetil colitis mimicking grade I GVHD of the gut. In our study, we used fluorescence in situ hybridization for the Y chromosome to document the lack of male donor lymphocytes in the female recipient colon biopsy. We suggest that molecular techniques including fluorescence in situ hybridization could be used to discriminate between MMF-related colitis and true GVHD in order to help guide therapy.
Kathryn C. Behling, MD, PhD
Department of Pathology, 132 South 10th Street, 285 Main Building
Philadelphia, PA 19107 (USA)
Tel. +1 215 955 6352, Fax +1 215 923 1969E-Mail firstname.lastname@example.org
Published online: December 9, 2009
Number of Print Pages : 6
Number of Figures : 1,
Case Reports in Gastroenterology
Vol. 3, No. 3, Year 2009 (Cover Date: September - December)
Journal Editor: Urrutia R. (Rochester, Minn.)
ISSN: NIL (Print), eISSN: 1662-0631 (Online)
For additional information: http://www.karger.com/CRG