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Table of Contents
Vol. 25, No. 6, 1991
Issue release date: 1991
Section title: Basic Science
Caries Res 1991;25:438–443
(DOI:10.1159/000261407)

Anticaries Effects of Polyphenolic Compounds from Japanese Green Tea

Otake S. · Makimura M. · Kuroki T. · Nishihara Y. · Hirasawa M.
Departments of aClinical Pathology and bMicrobiology, Nihon University School of Dentistry, Matsudo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Basic Science

Received: 7/20/1990
Accepted: 1/10/1991
Published online: 11/18/2009

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE

Abstract

The dental caries inhibiting effect of the extract from Japanese green tea, one of the most popular drinks in Japan, was studied both in vitro and in vivo. The crude tea polyphenolic compounds (designated Sun-phenon®) from the leaf of Camellia sinensis were found to effectively inhibit the attachment of Streptococcus mutans strain JC-2 (serotype c) to saliva-coated hydroxyapatide discs. Sunphenon was also inhibitory to water-insoluble glucan formation from sucrose by crude glucosyltransferase of S. mutans JC-2 (c). Among the tea catechins tested, (––)-epigallocatechin gallate and (––)-epicatechin gallate showed the most potent inhibition of the glucosyltransferase activity. Finally, significantly lower caries scores were observed in specific pathogen free rats infected with S. mutans JC-2 (c) and fed a cariogenic diet and/or drinking water containing 0.05% Sunphenon as compared with control rats not receiving polyphenolic compounds.


  

Author Contacts

Dr. Shigeo Otake, Department of Clinical Pathology, Nihon University School of Dentistry, 870-1 Sakaecho, Nishi-2, Matsudo-shi, Chiba-ken 271 (Japan)

  

Article Information

Received: July 20, 1990
Accepted after revision: January 10, 1991
Published online: November 18, 2009
Number of Print Pages : 6

  

Publication Details

Caries Research

Vol. 25, No. 6, Year 1991 (Cover Date: 1991)

Journal Editor: Shellis R.P. (Bristol)
ISSN: 0008-6568 (Print), eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


Article / Publication Details

First-Page Preview
Abstract of Basic Science

Received: 7/20/1990
Accepted: 1/10/1991
Published online: 11/18/2009

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: http://www.karger.com/CRE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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