The dental caries inhibiting effect of the extract from Japanese green tea, one of the most popular drinks in Japan, was studied both in vitro and in vivo. The crude tea polyphenolic compounds (designated Sun-phenon®) from the leaf of Camellia sinensis
were found to effectively inhibit the attachment of Streptococcus mutans
strain JC-2 (serotype c
) to saliva-coated hydroxyapatide discs. Sunphenon was also inhibitory to water-insoluble glucan formation from sucrose by crude glucosyltransferase of S. mutans
Among the tea catechins tested, (––)-epigallocatechin gallate and (––)-epicatechin gallate showed the most potent inhibition of the glucosyltransferase activity. Finally, significantly lower caries scores were observed in specific pathogen free rats infected with S. mutans
and fed a cariogenic diet and/or drinking water containing 0.05% Sunphenon as compared with control rats not receiving polyphenolic compounds.
Dr. Shigeo Otake, Department of Clinical Pathology, Nihon University School of Dentistry, 870-1 Sakaecho, Nishi-2, Matsudo-shi, Chiba-ken 271 (Japan)
Received: July 20, 1990
Accepted after revision: January 10, 1991
Published online: November 18, 2009
Number of Print Pages : 6
Vol. 25, No. 6, Year 1991 (Cover Date: 1991)
Journal Editor: Shellis R.P. (Bristol)
ISSN: 0008-6568 (Print), eISSN: 1421-976X (Online)
For additional information: http://www.karger.com/CRE
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