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Vol. 25, No. 6, 1991
Issue release date: 1991
Caries Res 1991;25:438–443

Anticaries Effects of Polyphenolic Compounds from Japanese Green Tea

Otake S. · Makimura M. · Kuroki T. · Nishihara Y. · Hirasawa M.
Departments of aClinical Pathology and bMicrobiology, Nihon University School of Dentistry, Matsudo, Japan

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The dental caries inhibiting effect of the extract from Japanese green tea, one of the most popular drinks in Japan, was studied both in vitro and in vivo. The crude tea polyphenolic compounds (designated Sun-phenon®) from the leaf of Camellia sinensis were found to effectively inhibit the attachment of Streptococcus mutans strain JC-2 (serotype c) to saliva-coated hydroxyapatide discs. Sunphenon was also inhibitory to water-insoluble glucan formation from sucrose by crude glucosyltransferase of S. mutans JC-2 (c). Among the tea catechins tested, (––)-epigallocatechin gallate and (––)-epicatechin gallate showed the most potent inhibition of the glucosyltransferase activity. Finally, significantly lower caries scores were observed in specific pathogen free rats infected with S. mutans JC-2 (c) and fed a cariogenic diet and/or drinking water containing 0.05% Sunphenon as compared with control rats not receiving polyphenolic compounds.

 goto top of outline Author Contacts

Dr. Shigeo Otake, Department of Clinical Pathology, Nihon University School of Dentistry, 870-1 Sakaecho, Nishi-2, Matsudo-shi, Chiba-ken 271 (Japan)

 goto top of outline Article Information

Received: July 20, 1990
Accepted after revision: January 10, 1991
Published online: November 18, 2009
Number of Print Pages : 6

 goto top of outline Publication Details

Caries Research

Vol. 25, No. 6, Year 1991 (Cover Date: 1991)

Journal Editor: Shellis R.P. (Bristol)
ISSN: 0008-6568 (Print), eISSN: 1421-976X (Online)

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