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Table of Contents
Vol. 56, No. 1, 2010
Issue release date: February 2010
Section title: Original Paper
Free Access
Ann Nutr Metab 2010;56:16–22

Early-Life Predictors of Higher Body Mass Index in Healthy Children

Lamb M.M.a · Dabelea D.a · Yin X.b · Ogden L.G.b · Klingensmith G.J.c · Rewers M.a, c · Norris J.M.a
aDepartment of Epidemiology, bDepartment of Biostatistics, University of Colorado Denver, and cBarbara Davis Center for Childhood Diabetes, Aurora, Colo., USA
email Corresponding Author

Dr. Jill M. Norris, MPH, PhD

University of Colorado Denver

13001 E. 17th Place, B119, Bldg. 500, Room W3139

Aurora, CO 80045 (USA)

Tel. +1 303 724 4428, Fax +1 303 724 4489, E-Mail jill.norris@ucdenver.edu

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Background/Aims: Childhood obesity tracks into adulthood, and may increase diabetes and cardiovascular disease risk in adulthood. Prospective analyses may better define the pathways between early life factors and greater childhood body mass index (BMI), a measure of obesity. Methods: The Diabetes Autoimmunity Study in the Young (DAISY) prospectively follows children from birth that are at increased genetic risk for type 1 diabetes. We examined longitudinal data for 1,178 DAISY subjects (mean age at last follow-up: 6.59 years (range: 2.0–11.5 years). Birth size and diabetes exposure in utero were collected in the enrollment interview. Infant diet information was collected via interviews throughout infancy. Infant weight gain and childhood BMI were measured at clinic visits. Results: Female gender, diabetes exposure in utero, larger size for gestational age, shorter breastfeeding duration, and more rapid infant weight gain predicted higher childhood BMI. Formal mediation analysis suggests the effect of shorter breastfeeding duration on childhood BMI may be mediated by more rapid infant weight gain. Also, the effect of diabetes exposure in utero on childhood BMI may be mediated by larger size for gestational age. Conclusion: We identified strong interrelationships between early life factors and childhood BMI. Understanding these pathways may aid childhood obesity prevention efforts.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 04, 2009
Accepted: October 02, 2009
Published online: November 27, 2009
Issue release date: February 2010

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

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