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Vol. 18, No. 4, 1999
Issue release date: July–August 1999
Section title: Original Paper
Neuroepidemiology 1999;18:194–202
(DOI:10.1159/000026211)

Association of Cigarette Smoking with Amyotrophic Lateral Sclerosis

Kamel F. · Umbach D.M. · Munsat T.L. · Shefner J.M. · Sandler D.P.
aNational Institute of Environmental Health Sciences, Research Triangle Park, N.C., bNew England Medical Center, and cHarvard Medical School, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/16/1999

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

We explored the relationship between amyotrophic lateral sclerosis (ALS) and cigarette smoking in a case-control study conducted in New England from 1993 to 1996. Recently diagnosed ALS cases (n = 109) were recruited from two major referral centers. Population controls (n = 256) were identified by random telephone screening. Data were analyzed by logistic regression. After adjusting for age, sex, region and education, ever having smoked cigarettes was associated with an increase in risk for ALS (odds ratio 1.7; 95% confidence interval 1.0–2.8). Average cigarettes smoked per day, years smoked and pack-years were all greater in cases than controls, but dose-response trends were not observed. Similar numbers of cases and controls had ever used alcohol, and only a small, nonsignificant association of drinks per month with ALS was observed. The association of cigarette smoking with ALS was not affected by adjusting for alcohol use. In contrast, the weak relationship of ALS with alcohol use was apparently due to confounding by smoking.


  

Author Contacts

Freja Kamel, PhD, MPH, Epidemiology Branch, MD A3-05
National Institute of Environmental Health Sciences
Box 12233, Research Triangle Park, NC 27709 (USA)
Tel. +1 919 541 1581, Fax +1 919 541 2511
E-Mail kamel@niehs.nih.gov

  

Article Information

Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 3, Number of References : 29

  

Publication Details

Neuroepidemiology
Founded 1982 by B.S. Schoenberg, continued by M. Alter (1989–1996)

Vol. 18, No. 4, Year 1999 (Cover Date: July-August 1999)

Journal Editor: P.B. Gorelick, Chicago, Ill.
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/journals/ned


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/16/1999

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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