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Vol. 29, No. 2, 2010
Issue release date: January 2010
Section title: Original Paper
Cerebrovasc Dis 2010;29:122–129
(DOI:10.1159/000262307)

Jugular Venous Reflux Affects Ocular Venous System in Transient Monocular Blindness

Chung C.-P. · Hsu H.-Y. · Chao A-C. · Cheng C.-Y. · Lin S.-J. · Hu H.-H.
Departments of aNeurology and bOphthalmology, Taipei Veterans General Hospital,and cInstitute of Clinical Medicine, National Yang-Ming University, Taipei, dSection of Neurology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, and eDepartment of Neurology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/6/2009
Accepted: 8/8/2009
Published online: 12/1/2009

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: The frequency of jugular venous reflux (JVR) is higher in patients with transient monocular blindness (TMB). We hypothesize that JVR influences ocular venous outflow, and resulting disturbances in cerebral and ocular venous circulation might be a cause of TMB. To substantiate this hypothesis, we aimed to demonstrate that: (1) TMB patients have vasculature changes in their retinal venules, and (2) JVR could influence ocular venous outflow, as revealed by dilated retinal venules. Methods: This study has 2 parts. The case-control study included 31 TMB patients and 31 age/gender-matched normal individuals, who all received fundus photography for retinal venule diameter comparisons. The Valsalva maneuver (VM) experiment included 30 healthy volunteers who received both color Doppler imaging of the internal jugular vein and fundus photography for retinal venule diameter measurement. Results: In the case-control study, TMB patients had a wider retinal venule diameter (184.5 ± 17.5 vs. 174.3 ± 16.2 µm, right eye, p = 0.023; 194.20 ± 24.6 vs. 176.6 ± 19.5 µm, left eye, p = 0.017), especially TMB patients with JVR. The VM experiments showed that the presence of JVR was associated with a greater increase in retinal venule diameters during VM in the subjects’ right eye (14.27 ± 11.16 vs. 2.75 ± 3.51%, JVR vs. non-JVR, p = 0.0002) and left eye (10.06 ± 6.42 vs. 1.80 ± 2.03%, p = 0.0003). Conclusions: These findings provide evidence that frequently occurring JVR associated with TMB impedes ocular venous outflow, and the subsequent disturbances in ocular venous circulation may be a cause of TMB.


  

Author Contacts

Prof. Han-Hwa Hu
Department of Neurology, Taipei Veterans General Hospital
201 Sec. 2, Shihpai Road
Peitou, Taipei 11217 (Taiwan)
Tel. +886 2 2875 7046, Fax +886 2 2873 9241, E-Mail hhhu@vghtpe.gov.tw

  

Article Information

Received: April 6, 2009
Accepted: August 8, 2009
Published online: December 1, 2009
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 2, Number of References : 33

  

Publication Details

Cerebrovascular Diseases

Vol. 29, No. 2, Year 2010 (Cover Date: January 2010)

Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/6/2009
Accepted: 8/8/2009
Published online: 12/1/2009

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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