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Table of Contents
Vol. 114, No. 3, 2010
Issue release date: February 2010
Section title: Original Paper
Nephron Exp Nephrol 2010;114:e107–e116
(DOI:10.1159/000262318)

Poor Cell Survival Limits the Beneficial Impact of Mesenchymal Stem Cell Transplantation on Acute Kidney Injury

Burst V.R.a · Gillis M.a · Pütsch F.a · Herzog R.a · Fischer J.H.b · Heid P.b · Müller-Ehmsen J.c · Schenk K.c · Fries J.W.U.d · Baldamus C.A.a · Benzing T.a
aRenal Division, Department of Medicine, bInstitute of Experimental Medicine, cLaboratory of Muscle Research and Molecular Cardiology, Department of Medicine, and dInstitute of Pathology, University of Cologne, Cologne, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 10, 2009
Accepted: September 02, 2009
Published online: December 02, 2009
Issue release date: February 2010

Number of Print Pages: 1
Number of Figures: 6
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE

Abstract

Background: Although renal tubular epithelium has a great capacity for repair it has been suggested that the administration of mesenchymal stem cells may accelerate the recovery following severe ischemic injury. Methods: Here we analyzed the survival rate and organ distribution of transplanted mesenchymal stem cells as well as their contribution to kidney regeneration after ischemic renal injury using functional tests, histological examination as well as quantitative real-time PCR. Results: Intravenously injected stem cells were mainly trapped in lungs and liver. One hour after injection, less than 1% of the injected stem cells could be detected in the injured kidneys. These cells disappeared within the first few days and did not replace renal epithelial cells precluding substantial transdifferentiation. To clarify whether reinforced stem cell delivery might promote sustained survival or conversion to tubular epithelia, stem cells were directly injected into the injured kidneys. Although these grafted cells also did not show sustained survival or contribute to structural renal repair, stem cell injection was associated with a significant but transient initial decrease in serum creatinine. Conclusion: These data suggest that mesenchymal stem cells do not significantly contribute to epithelial renewal after ischemic injury, promoting the idea that the major impact of cell-based therapy for acute kidney injury may result from paracrine or endocrine effects unrelated to stem cell transdifferentiation.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 10, 2009
Accepted: September 02, 2009
Published online: December 02, 2009
Issue release date: February 2010

Number of Print Pages: 1
Number of Figures: 6
Number of Tables: 1

ISSN: (Print)
eISSN: 1660-2129 (Online)

For additional information: http://www.karger.com/NEE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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