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Vol. 44, No. 1, 2010
Issue release date: January 2010
Section title: Original Paper
Eur Surg Res 2010;44:30–36
(DOI:10.1159/000262324)

Ischemia-Modified Albumin Reduction after Coronary Bypass Surgery Is Associated with the Cardioprotective Efficacy of Cold-Blood Cardioplegia Enriched with N-Acetylcysteine: A Preliminary Study

Karahan S.C.a · Koramaz İ.b · Altun G.b · Uçar U.a · Topbaş M.c · Menteşe A.a · Kopuz M.a
Departments of aBiochemistry, bCardiovascular Surgery and cPublic Health, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/26/2009
Accepted: 6/21/2009
Published online: 12/1/2009
Issue release date: January 2010

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR

Abstract

Background: The aims of this preliminary study were to determine the alteration of serum ischemia-modified albumin (IMA) levels and to investigate whether IMA may be used as an indicator of the cardioprotective efficacy of N-acetylcysteine (NAC) in patients undergoing coronary bypass grafting (CABG). Patients and Methods: Forty-four patients were randomized into one of two groups on the basis of cardioplegic strategies, either cold-blood cardioplegia enriched with NAC (50 mg/kg) or cold-blood cardioplegia alone. Serum IMA, cardiac troponin T (cTnT) and malondialdehyde (MDA) levels determined in NAC-enriched patients before and after CABG were compared with those of the NAC-free group. The albumin cobalt binding assay was used for IMA determination. Results: Serum IMA levels were significantly elevated after cross-clamping and peaked at 6 h after reperfusion in the two groups. In NAC-enriched patients, IMA levels determined 6, 12, 24 and 48 h after reperfusion were significantly lower than those of the NAC-free group (p ≤ 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). IMA returned to baseline 24 h after reperfusion differently from cTnT and MDA in the NAC-enriched group. Conclusions: IMA may be used as not only an indicator of myocardial ischemia-reperfusion injury, but also as a useful indicator of the cardioprotective effect of NAC in CABG.

© 2009 S. Karger AG, Basel


  

Author Contacts

S. Caner Karahan, MD
Department of Biochemistry
Karadeniz Technical University, Faculty of Medicine
TR–61080 Trabzon (Turkey)
Tel. +90 533 418 6475, Fax +90 462 325 2821, E-Mail scaner61@yahoo.com

  

Article Information

Received: February 26, 2009
Accepted after revision: July 21, 2009
Published online: December 1, 2009
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 2, Number of References : 29

  

Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 44, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Kempski O. (Mainz)
ISSN: 0014-312X (Print), eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/26/2009
Accepted: 6/21/2009
Published online: 12/1/2009
Issue release date: January 2010

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


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