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Vol. 13, No. 6, 2010
Issue release date: August 2010
Section title: Original Paper
Public Health Genomics 2010;13:353–359
(DOI:10.1159/000262330)

Family History of Diabetes and Prevalence of the Metabolic Syndrome in U.S. Adults without Diabetes: 6-Year Results from the National Health and Nutrition Examination Survey (1999–2004)

Ghosh A. · Liu T. · Khoury M.J. · Valdez R.
aBiomedical Research Laboratory, Department of Anthropology, Visva Bharati University, Sriniketan, India; bOffice of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta,Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 7/30/2009
Published online: 11/26/2009

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG

Abstract

Background/Aims: Type 2 diabetes and cardiovascular disease share risk factors. The influence of family history of diabetes on the odds of having metabolic syndrome has not been estimated for the U.S. population. Our objective was to quantify this association in a national sample of U.S. adults without diabetes. Methods: The sample included 4,937 individuals from the National Health and Nutrition Examination Survey (NHANES) (1999–2004). Familial risk of diabetes was classified in 3 strata according to the combination of relatives affected. Metabolic syndrome was defined according to guidelines issued by 4 groups or organizations. The prevalence and odds of this syndrome were compared among familial risk strata after controlling for relevant risk factors. Results: Overall, depending on the definition and after controlling for key variables, people with a moderate familial risk of diabetes, and people with a high familial risk of diabetes were between 1.4 and 1.6, and 1.6 and 1.8 times as likely, respectively, to have metabolic syndrome compared to people with average familial risk. Conclusion: In a nationally representative sample of U.S. adults without diabetes, family history of diabetes shows a significant, independent association with metabolic syndrome and its traits. This association supports the idea that shared genes and environment contribute to the expression of complex traits such as diabetes and the metabolic syndrome.


  

Author Contacts

Rodolfo Valdez, PhD
Office of Public Health Genomics, Centers for Disease Control and Prevention
1600 Clifton Rd., NE, Mailstop E-61
Atlanta, GA 30333 (USA)
Tel. +1 404 498 0072, Fax +1 404 498 0140, E-Mail rvaldez@cdc.gov

  

Article Information

Accepted after revision: July 30, 2009
Received: April 22, 2009
Published online: November 26, 2009
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 4, Number of References : 28

  

Publication Details

Public Health Genomics

Vol. 13, No. 6, Year 2010 (Cover Date: August 2010)

Journal Editor: Knoppers B.M. (Montreal, Que.), Brand A. (Maastricht), Burke W. (Seattle, Wash.), Khoury M.J. (Atlanta, Ga.)
ISSN: 1662-4246 (Print), eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 7/30/2009
Published online: 11/26/2009

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 4

ISSN: 1662-4246 (Print)
eISSN: 1662-8063 (Online)

For additional information: http://www.karger.com/PHG


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