Pediatric Neuroendocrinology

Editor(s): Loche S. (Cagliari) 
Cappa M. (Rome) 
Ghizzoni L. (Turin) 
Maghnie M. (Genova) 
Savage M.O. (London) 
Table of Contents
Vol. 17, No. , 2010
Section title: Paper
Loche S, Cappa M, Ghizzoni L, Maghnie M, Savage MO (eds): Pediatric Neuroendocrinology. Endocr Dev. Basel, Karger, 2010, vol 17, pp 11–21

Role of Sleep and Sleep Loss in Hormonal Release and Metabolism

Leproult R. · Van Cauter E.
Department of Medicine, University of Chicago, Chicago, Ill., USA

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Compared to a few decades ago, adults, as well as children, sleep less. Sleeping as little as possible is often seen as an admirable behavior in contemporary society. However, sleep plays a major role in neuroendocrine function and glucose metabolism. Evidence that the curtailment of sleep duration may have adverse health effects has emerged in the past 10 years. Accumulating evidence from both epidemiologic studies and well-controlled laboratory studies indicates that chronic partial sleep loss may increase the risk of obesity and weight gain. The present chapter reviews epidemiologic studies in adults and children and laboratory studies in young adults indicating that sleep restriction results in metabolic and endocrine alterations, including decreased glucose tolerance, decreased insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. Altogether, the evidence points to a possible role of decreased sleep duration in the current epidemic of obesity. Bedtime extension in short sleepers should be explored as a novel behavioral intervention that may prevent weight gain or facilitate weight loss. Avoiding sleep deprivation may help to prevent the development of obesity, particularly in children.

 goto top of outline Author Contacts

Eve Van Cauter, PhD, Department of Medicine, MC1027, 5841 S. Maryland Avenue, Chicago, IL 60637 (USA), Tel. +1 773 702 0169, Fax +1 773 702 7686, E-Mail

 goto top of outline Article Information

Number of Print Pages : 11

 goto top of outline Publication Details

Book Serie: Endocrine Development, Vol. 17, Year 2010

Editor(s): Loche, S. (Cagliari); Cappa, M. (Rome); Ghizzoni, L. (Turin); Maghnie, M. (Genova); Savage, M.O. (London)
ISSN: 1421-7082 (Print), eISSN: 1662-2979 (Online)

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Book Title: Pediatric Neuroendocrinology (Workshop, Villasimius, May 2009)

Editor(s): Loche S, Cappa M, Ghizzoni L, Maghnie M, Savage MO (eds)

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