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Table of Contents
Vol. 8, No. 2, 1993
Issue release date: 1993
Section title: Paper
Fetal Diagn Ther 1993;8:109–113
(DOI:10.1159/000263757)

Renal Tubular Damage in Fetuses with Intrauterine Growth Retardation

Pachi A.a · Lubrano R.b · Maggi E.a · Giancotti A.a · Giampá G.a · Elli M.c · Mannarino O.b · Castello M.A.b
a4th Department of Obstetrics and Gynecology, and b1st Department of Pediatrics, ‘La Sapienza’, University of Rome, cDepartment of Surgery, 2nd University of Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 01, 1991
Accepted: July 08, 1992
Published online: November 26, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Fetal hypoxemia is one of the most frequent causes of intrauterine growth retardation (IUGR). In chronic fetal hypoxia, peripheral blood flow and blood flow to the kidneys is reduced to maintain heart, brain and adrenal perfusion, the ‘brain-sparing effect’. In kidneys the cells of the proximal tubules seem to be most sensitive to hypoxia caused by reduced blood flow. Damage to the cells of the proximal tubules can be easily diagnosed by urinary levels of N-acetyl-β-D-glucosaminidase (NAG), an enzyme present in high concentrations in these cells. The aim of the present study was to define the levels of NAG in the amniotic fluid, to diagnose damage to the cells of the proximal renal tubules in fetuses, and to correlate them with a detectable brain-sparing effect. The study was conducted on a total of 55 pregnancies: 9 pregnancies were complicated by IUGR, and the remaining 46 normal pregnancies formed the control group. Higher levels of NAG were detected in the amniotic fluid from the IUGR-complicated pregnancies (p < 0.025). In particular, fetuses with IUGR had high levels of NAG in the amniotic fluid in 8 of 9 cases (+ 2 SD compared with controls), while 1 had normal concentrations. In the 8 cases with high concentrations of NAG in the amniotic fluid, velocimetric Doppler study documented a brain-sparing effect, which was not present in the 1 fetus with normal NAG levels. In conclusion, high levels of NAG in the amniotic fluid may identify in uterus fetuses with renal damage. These individuals are in need of stricter peri- and postnatal care as, in the case of perinatal anoxia, this particular condition may be one of the causes concurrent in the onset of postnatal acute renal failure.

© 1993 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 01, 1991
Accepted: July 08, 1992
Published online: November 26, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.