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Table of Contents
Vol. 10, No. 2, 1995
Issue release date: 1995
Section title: Paper
Fetal Diagn Ther 1995;10:101–105
(DOI:10.1159/000264214)

Survival in Non-Immune Hydrops fetalis without Malformation or Chromosomal Abnormalities after Invasive Treatment

Ayida G.A.a · Soothill P.W.b · Rodeck C.H.b
aQueen Charlotte’s and Chelsea Hospital, and bFetal Medicine Unit, Department of Obstetrics and Gynaecology, University College London Medical School, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: March 09, 1994
Accepted: August 29, 1994
Published online: November 27, 2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

The aim of the study was to determine the outcome of fetuses with non-immune hydrops (NIH) following modern invasive investigation and therapy. This prospectively planned observational study involved 23 women with singleton fetuses in whom a diagnosis of NIH was made in our fetal medicine unit in 1 year. After investigation and counselling 15 of the 23 women opted for termination of pregnancy (10 chromosomal and 5 structural abnormalities) and there was 1 intrauterine fetal death before therapy was attempted. One case with diaphragmatic hernia was treated with shunting which successfully reversed the hydrops, the pregnancy continued to term, the malformation was surgically corrected but the neonate died from pulmonary hypoplasia. In the remaining 6 cases structural and chromosomal abnormalities were excluded. One had amniotic fluid drainage for polyhydramnios but despite this delivered at 30 weeks’ gestation and the neonate died on day 5. The remaining 5 cases had fetal therapy between 22 and 32 weeks’ gestation (4 shunt insertions, 1 blood transfusion) and in all the hydrops reversed and the pregnancy continued to at least 35 weeks’ gestation. All 5 neonates were discharged from hospital alive and well. Fetal therapy in cases of NIH with normal structure and karyotype was associated with a very good outcome. Giving a uniform poor prognosis is no longer justified because if other fetal abnormalities are excluded, in utero treatment, reversal of the hydrops and survival are often possible. We recommend urgent referral of these cases to a fetal medicine unit.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: March 09, 1994
Accepted: August 29, 1994
Published online: November 27, 2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.