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Table of Contents
Vol. 152, No. 2, 2010
Issue release date: May 2010
Section title: Original Paper
Int Arch Allergy Immunol 2010;152:178–183
(DOI:10.1159/000265539)

Anaphylaxis to Wheat Flour-Derived Foodstuffs and the Lipid Transfer Protein Syndrome: A Potential Role of Wheat Lipid Transfer Protein Tri a 14

Palacin A.a · Bartra J.b · Muñoz R.b · Diaz-Perales A.a · Valero A.b · Salcedo G.a
aDepartamento de Biotecnología, E.T.S. Ingenieros Agrónomos, Universidad Politécnica, Madrid, bUnitat d’Allèrgia, Servei de Pneumologia i Allèrgia Respiratòria, Hospital Clínic, Universitat de Barcelona, Barcelona, España

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 2009
Accepted: August 31, 2009
Published online: December 16, 2009
Issue release date: May 2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker’s asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called ‘LTP syndrome’. Methods: Eight adult patients showing anaphylaxis after ingestion of wheat-derived foodstuffs were selected. A homemade wheat extract, purified natural (n) and recombinant (r) Tri a 14, and peach fruit and Artemisia pollen LTP allergens Pru p 3 and Art v 3 were subjected to skin prick test, specific IgE determination (ELISA) and IgE immunodetection assays. Results: All tests were positive in the 8 selected patients with the homemade extract. Positive skin prick test responses to nTri a 14, Pru p 3 and Art v 3 were found in 5/8, 6/8 and 4/4 patients, respectively. Specific IgE determined by ELISA assays was detected in 6 to nTri a 14 and rTri a 14, in 4 to Pru p 3 and in 3 to Art v 3 out of 8 individual sera tested, whereas all these sera showed IgE binding to nTri a 14 and Pru p 3 in immunodetection after SDS-PAGE separation. Conclusions: Tri a 14 seems to be a relevant allergen in patients with anaphylaxis after ingestion of wheat flour foodstuffs, according to in vitro and in vivo results. Clinical history of the analyzed patients, together with sensitization to peach Pru p 3 and Artemisia pollen Art v 3, suggests that 6 of them suffer from LTP syndrome.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 2009
Accepted: August 31, 2009
Published online: December 16, 2009
Issue release date: May 2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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