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Vol. 82, No. 4, 2010
Issue release date: August 2010
Section title: Original Paper
Digestion 2010;82:221–228
(DOI:10.1159/000265549)

Impact of Gluten Withdrawal on Health-Related Quality of Life in Celiac Subjects: An Observational Case-Control Study

Tontini G.E.a, b · Rondonotti E.a, c · Saladino V.c · Saibeni S.d · de Franchis R.a, c · Vecchi M.a, b
aUniversity of Milan, Milan, bIRCCS Policlinico San Donato, San Donato Milanese, cFondazione IRCCS Ospedale Policlinico, Regina Elena e Mangiagalli, and dAzienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/8/2009
Accepted: 12/3/2009
Published online: 6/24/2010
Issue release date: August 2010

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Aims: To evaluate health-related quality of life (HRQoL) in celiac disease (CD) patients at the time of diagnosis and during a gluten-free diet (GFD). Patients and Methods: We enrolled 43 adult CD patients (18 with a typical and 15 with an atypical clinical presentation, and 10 with dermatitis herpetiformis, DH) and 86 age- and sex-matched healthy controls. We administered the Short Form 36 Health Survey (SF-36) questionnaire at diagnosis and after 1, 12 and 24 months of a GFD. Results: At the time of diagnosis CD patients showed significantly lower SF-36 scores than controls; this figure was observed in women but not in men. At baseline, both typical and atypical CD patients had lower SF-36 scores than controls, while DH patients showed a SF-36 profile comparable to that of controls. During a GFD the SF-36 scores improved continuously in CD patients and in the female subgroup, becoming similar to those of matched controls at 1-year follow-up. After gluten withdrawal typical and atypical CD patients improved their SF-36 scores and reached values comparable to those of controls. Conclusions: At diagnosis, CD patients perceived a poor HRQoL; this figure appears to be mostly associated with female gender. In all subgroups of CD patients with a low HRQoL at diagnosis, the GFD allowed progressive restoration of HRQoL perception.

© 2010 S. Karger AG, Basel


  

Author Contacts

Gian Eugenio Tontini, MD
IRCCS Policlinico San Donato
Via Morandi 30
IT–20097 San Donato Milanese (Italy)
Tel./Fax +39 02 5277 4655, E-Mail gianeugeniotontini@libero.it

  

Article Information

Received: September 8, 2009
Accepted: December 3, 2009
Published online: June 24, 2010
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 31

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 82, No. 4, Year 2010 (Cover Date: August 2010)

Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/8/2009
Accepted: 12/3/2009
Published online: 6/24/2010
Issue release date: August 2010

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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