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Vol. 91, No. 1, 2010
Issue release date: January 2010
Section title: Neuroendocrine Tumors
Neuroendocrinology 2010;91:101–109
(DOI:10.1159/000265561)

Impact of Multiphase 68Ga-DOTATOC-PET/CT on Therapy Management in Patients with Neuroendocrine Tumors

Ruf J. · Heuck F. · Schiefer J. · Denecke T. · Elgeti F. · Pascher A. · Pavel M. · Stelter L. · Kropf S. · Wiedenmann B. · Amthauer H.
aKlinik für Radiologie und Nuklearmedizin, and bInstitut für Biometrie und Medizinische Informatik, Universitätsklinikum Magdeburg A.ö.R, Magdeburg, cMedizinische Klinik m. S. Hepatologie und Gastroenterologie, Charité Centrum 13 für Innere Medizin mit Kardiologie, Gastroenterologie, und Nephrologie, dKlinik Strahlenheilkunde, Charité Centrum 6 für diagnostische und interventionelle Radiologie und Nuklearmedizin, and eKlinik für Allgemein-, Viszeral- und Transplantationschirurgie, Charité Centrum 8 für Chirurgische Medizin, Campus Virchow-Klinikum, Charité-Universitätsmedizin, Berlin, Germany; fNuclear Medicine Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York City, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Tumors

Received: 5/7/2009
Accepted: 10/2/2009
Published online: 12/9/2009

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 3

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

Abstract

Aim: Retrospective evaluation of the impact of integrated positron emission tomography/computed tomography (PET/CT) using 68Ga-DOTA(0)-Phe(1)-Tyr(3)-octreotide (68Ga-DOTATOC) on the therapeutic management of patients with neuroendocrine tumors (NET). Methods: The 68Ga-DOTATOC-PET/CT data of 66 patients (31 male, 35 female; age: 29–79, mean age: 56 years) with known or suspected NET were included. Imaging data (PET and triple-phase contrast-enhanced CT) were evaluated in consensus by two readers for the visualization of NET manifestations. Combined PET/CT, clinical and imaging follow-up as well as histopathology (if available) served as the reference standard. In order to assess the impact of the respective submodalities on the therapeutic strategy chosen, the results were compared to the treatment decision made by the interdisciplinary NET tumor board of our institution. Results: Two of the initial 66 patients included did not suffer from NET according to further immunohistopathological examination. In 50 of the remaining 64 (78%) NET patients, a total of 181 NET manifestations were detected by PET/CT. 59/181 (32.6%) were detected by one submodality only (CT 17.1%, PET 15.5%, p for comparison of both = 0.459). Combined PET/CT reading had an impact on the therapeutic management in 24 of 64 (38%) NET patients: primary resection (n = 5), curative lymph node resection (n = 1), initiation/switch of chemotherapy (CTx) due to progressive disease (n = 10), no surgery due to systemic disease (n = 2), radiopeptide receptor therapy instead of CTx (n = 1), additional bisphosphonate therapy (n = 4), and hepatic brachytherapy (n = 1). In 12 of 24 (50%) of these patients, relevant findings were detected by a single submodality only: CT (n = 5), PET (n = 7); p for comparison = 0.774). Conclusion:68Ga-DOTATOC-PET/CT influences therapeutic management in about one third of patients examined. CT and PET are comparably sensitive, deliver complementary information and equally contribute to therapeutic decision-making. Thus, despite the merits of the PET modality, the CT component must not be neglected and an optimized multiphase CT protocol is recommended.


  

Author Contacts

Dr. Juri Ruf
Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R
Otto-von-Guericke Universität, Leipziger Strasse 44
DE–39120 Magdeburg (Germany)
Tel. +49 391 67 13005, Fax +49 391 67 13016, E-Mail juri.ruf@med.ovgu.de

  

Article Information

Received: May 7, 2009
Accepted after revision: October 2, 2009
Published online: December 9, 2009
Number of Print Pages : 9
Number of Figures : 2, Number of Tables : 3, Number of References : 34

  

Publication Details

Neuroendocrinology (International Journal for Basic and Clinical Studies on Neuroendocrine Relationships)

Vol. 91, No. 1, Year 2010 (Cover Date: January 2010)

Journal Editor: Millar R.P. (Edinburgh)
ISSN: 0028-3835 (Print), eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


Article / Publication Details

First-Page Preview
Abstract of Neuroendocrine Tumors

Received: 5/7/2009
Accepted: 10/2/2009
Published online: 12/9/2009

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 3

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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