Apolipoprotein E Genotype and SchizophreniaChen J.-Y. · Hong C.-J. · Chiu H.-J. · Lin C.-Y. · Bai Y.-M. · Song H.-L. · Lai H.-C. · Tsai S.-J.
aSection of Psychiatry, Yu-Li Veterans Hospital, bDivision of Psychiatry, School of Medicine, National Yang-Ming University, and cDepartment of Psychiatry, Veterans General Hospital, Taipei, Taiwan, ROC
Schizophrenic disorders are complex genetic disorders and may involve multiple genes of small effect. The presence of apolipoprotein E (apoE) is associated with several neuropsychiatric disorders. Previous studies on apoE genotype distribution in schizophrenia have reported conflicting findings. We studied the genotype frequencies in a large group of schizophrenic patients. The genotype distribution was significantly different between the schizophrenic patients and the control subjects. Persons who were σ3 carriers have an increased risk of schizophrenia. This result suggests that apoE isoforms may play a functional role in the pathogenesis of schizophrenic disorders. Some possible mechanisms regarding the effect of apoE on the development of schizophrenia are discussed.
Shih-Jen Tsai, MD
Department of Psychiatry, Veterans General Hospital-Taipei
No. 201, Shih-Pai Road, Sec. 2, 11217 Taipei, Taiwan (ROC)
Tel. +886 2 28757027 ext. 276, Fax +886 2 28757592
The experiments in this study were performed in the Molecular Biology Laboratory, Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC.
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 22
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)
Vol. 39, No. 3, Year 1999 (Cover Date: Released April 1999)
Journal Editor: J. Mendlewicz, Brussels
ISSN: 0302–282X (print), 1423–0224 (Online)
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