Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosaCotrufo P. · Monteleone P. · d’Istria M. · Fuschino A. · Serino I. · Maj M.
aInstitute of Psychiatry and bDepartment of Fisiologia Umana and Funzioni Biologiche Integrate ‘F. Bottazzi’, University of Naples SUN, Naples, Italy
Increased aggressiveness frequently occurs in patients with bulimia nervosa (BN), but its neurobiological correlates have been poorly investigated. In this study, we investigated possible relationships between such clinical measure and blood levels of endogenous hormones in patients with BN. Morning plasma levels of testosterone, 17β-estradiol, prolactin (PRL) and cortisol were measured in 33 bulimic women and 22 healthy female controls. The eating-related psychopathology, depression and aggressiveness were rated by specific psychometric scales. Bulimic patients showed decreased plasma levels of PRL and 17β-estradiol, and increased concentrations of cortisol and testosterone. Moreover, patients scored higher than healthy controls on rating scales assessing eating-related psychopathology, depressive symptoms and aggressiveness. A significant positive correlation was found between testosterone plasma levels and aggressiveness in patients but not in controls. These findings suggest that in BN, increased plasma levels of testosterone may play a role in the modulation of aggressiveness.
Institute of Psychiatry, University of Naples SUN
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Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 24
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Founded 1975 by J. Mendlewicz (Brussels)
Official Journal of the International Pharmaco-EEG Society (IPEG)
Vol. 42, No. 2, Year 2000 (Cover Date: Released July 2000)
Journal Editor: J. Mendlewicz, Brussels; B. Saletu, Vienna; P. Netter, Giessen; W.M. Herrmann, Berlin
ISSN: 0302–282X (print), 1423–0224 (Online)
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