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Vol. 23, No. 6, 1991
Issue release date: 1991
Section title: Paper
Ophthalmic Res 1991;23:303–308
(DOI:10.1159/000267127)

Influence of Iodide on Cataractogenesis in Emory Mice

Buchberger W.a · Winkler R.b · Moser M.b · Rieger G.c
Departments of aChemistry, bPhysiology, and cOphthalmology, Paracelsus Institute, Bad Hall, Austria

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 10/11/1990
Accepted: 6/7/1991
Published online: 12/10/2009
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE

Abstract

Cataract development was studied in two groups of Emory mice by periodical biomicroscopic examinations (beginning at 5 weeks of age) and by a final evaluation of water-soluble SH groups in the lenses. The experimental group was given 256 μg iodide/kg body weight with the drinking water throughout the study. The untreated control group received tap water. Iodide treatment induced a delay of cataract formation, resulting in a significant reduction of the time to progress from cataract degree 1 to degree 2 (iodide-treated group 12.8 ± 1.7 weeks, untreated group 9.9 ± 1.0 weeks; p < 0.025). A still significant difference in the degree of cataract was also found between the two groups at week 47 of age. No difference was found in the content of water-soluble SH groups. The results are discussed in relation to the known antioxidant and OH-scavenging effect of iodide and to the oxidative changes in the lens occurring during progression of cataract development.

© 1991 S. Karger AG, Basel


  

Author Contacts

Dr. G. Rieger, Augenabteilung des Paracelsus-Instituts, A-4540 Bad Hall (Austria)

  

Article Information

Received: October 11, 1990
Accepted: June 7, 1991
Published online: December 10, 2009
Number of Print Pages : 6

  

Publication Details

Ophthalmic Research (Journal for Research in Experimental and Clinical Ophthalmology)

Vol. 23, No. 6, Year 1991 (Cover Date: 1991)

Journal Editor: Pleyer U. (Berlin)
ISSN: 0030-3747 (Print), eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 10/11/1990
Accepted: 6/7/1991
Published online: 12/10/2009
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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