Cataract development was studied in two groups of Emory mice by periodical biomicroscopic examinations (beginning at 5 weeks of age) and by a final evaluation of water-soluble SH groups in the lenses. The experimental group was given 256 μg iodide/kg body weight with the drinking water throughout the study. The untreated control group received tap water. Iodide treatment induced a delay of cataract formation, resulting in a significant reduction of the time to progress from cataract degree 1 to degree 2 (iodide-treated group 12.8 ± 1.7 weeks, untreated group 9.9 ± 1.0 weeks; p < 0.025). A still significant difference in the degree of cataract was also found between the two groups at week 47 of age. No difference was found in the content of water-soluble SH groups. The results are discussed in relation to the known antioxidant and •
OH-scavenging effect of iodide and to the oxidative changes in the lens occurring during progression of cataract development.
Dr. G. Rieger, Augenabteilung des Paracelsus-Instituts, A-4540 Bad Hall (Austria)
Received: October 11, 1990
Accepted: June 7, 1991
Published online: December 10, 2009
Number of Print Pages : 6
Ophthalmic Research (Journal for Research in Experimental and Clinical Ophthalmology)
Vol. 23, No. 6, Year 1991 (Cover Date: 1991)
Journal Editor: Pleyer U. (Berlin)
ISSN: 0030-3747 (Print), eISSN: 1423-0259 (Online)
For additional information: http://www.karger.com/ORE
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