Antioxidant Therapy in the Treatment of Experimental Acute Corneal InflammationAlio J.L. · Ayala M.J. · Mulet M.E. · Artola A. · Ruiz J.M. · Bellot J.
Division of Ophthalmology, Laboratory of Ocular Inflammation, University of Alicante, Medical School, Alicante, Spain
To ascertain the effectiveness of topical antioxidant therapy on acute corneal inflammation, we have studied the effectiveness of topical treatment with a saline solution and with antioxidants such as 0.2% superoxide dismutase and 0.5% dimethylthiourea (DMTU) in a controlled experimental study. The evolution of the inflammatory process was evaluated by a multimodel approach, including computer-assisted planimetry of the corneal ulcer and infiltrate, ultrasonic pachymetry, luminol-amplified chemiluminescence and the study of corneal transparency by direct spectral spectrophotometry transmittance. The experimental model was a corneal ulcer created by a 60-second application of 1 N sodium hydroxide. Topical treatment with DMTU was shown to significantly improve all parameters tested, while superoxide dismutase reduced only the corneal ulcers. Antioxidant topical therapy with DMTU was shown to be efficient in reducing the inflammatory reaction that occurs during acute corneal inflammation. This suggests that antioxidant therapy could be considered as a complementary treatment in the pharmacological modulation of acute corneal inflammation.
© 1995 S. Karger AG, Basel
J. L. Alio, MD, PhD, Division of Ophthalmology, Laboratory of Ocular Inflammation, University of Alicante, Medical School, San Vicente del Raspeig, E-03690 Alicante (Spain)
Received: April 6, 1993
Accepted: November 8, 1994
Published online: December 11, 2009
Number of Print Pages : 8
Ophthalmic Research (Journal for Research in Experimental and Clinical Ophthalmology)
Vol. 27, No. 3, Year 1995 (Cover Date: 1995)
Journal Editor: Pleyer U. (Berlin)
ISSN: 0030-3747 (Print), eISSN: 1423-0259 (Online)
For additional information: http://www.karger.com/ORE