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Vol. 69, No. 3, 2010
Issue release date: April 2010
Gynecol Obstet Invest 2010;69:190–192

Severe Transient Leukopenia following Hysterosalpingography

Kovoor E.T. · Morgan G.
Department of Obstetrics and Gynaecology, Kings Mill Hospital, Sutton-in-Ashfield, UK

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Severe anaphylaxis to contrast media used in hysterosalpingography is very rare. Leukopenia may sometimes be seen in severe anaphylaxis associated with shock. This case report is about an atypical presentation of anaphylaxis following the injection of Conray 280 for hysterosalpingography. The patient had severe leukopenia without other associated features of anaphylaxis that resolved spontaneously after 48 h. This type of reaction to Conray 280 has not been reported before.

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Elias Kovoor
22 Little Holland Gardens
Nottingham NG16 1AY (UK)
Tel./Fax +44 776 600 0146, E-Mail

 goto top of outline Article Information

Received: March 10, 2009
Accepted after revision: October 27, 2009
Published online: December 21, 2009
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 11

 goto top of outline Publication Details

Gynecologic and Obstetric Investigation

Vol. 69, No. 3, Year 2010 (Cover Date: April 2010)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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  2. Elias J: Systemic reaction to radiocontrast media during hysterodalpingography. J Allergy Clin Immunol 1980;66:242.

    External Resources

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  7. Thurmond AS, Hedgpeth PL, Scanlan RM: Selective injection of contrast media: inflammatory effects on rabbit fallopian tubes. Radiology 1991;180:97–99.
  8. Moore DE, Segars JH, Jr, Winfield AC, Page DL, Eisenberg AD, Holburn GE: Effects of contrast agents on the fallopian tube in a rabbit model. Radiology 1990;176:721–744.
  9. Winfield AC, Henderson-Slayden R, Wentz AC, Harding DR: Hysterosalpingography: comparison of Conray 60 and Sinografin. AJR Am J Roentgenol 1982;138:559–560.
  10. Parker CW. Allergic reactions in man. Pharmacol Rev 1982;34:85–104.
  11. Wells PW, Eyre P, Lumsden JH: Hematological and pathological changes in acute systemic anaphylaxis in calves: effects of pharmacological agents. Can J Comp Med 1973;37:119–129.

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