Experimental Models of Stress and Pain: Do They Help to Develop New Therapies?Bradesi S. · Mayer E.A.
UCLA Center for Neurobiology of Stress, Departments of Medicine, Physiology and Psychiatry, David Geffen School of Medicine at UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, Calif., USA
The majority of functional gastrointestinal disorders are characterised by recurrent abdominal pain, with stress playing an important role in first onset and exacerbation of existing symptoms. These disorders are currently defined by symptom criteria, while their pathophysiology remains controversial and incompletely understood. Modeling these disorders in humans and animals has been difficult. While some of the models have adequate face and construct validity, the predictive validity of most of the models has been disappointing, which has put into question the traditional modeling approach. Similar problems have been encountered in drug development for pain and psychiatric disorders. New approaches have been proposed in the form of reverse translation, which include better characterisation of biological intermediate phenotypes in human disease which can be modeled in humans and in animals. Continuation of the current approach focusing on complex clinical phenotypes is likely to be ineffective for the development of novel and effect treatments.
Sylvie Bradesi, PhD
University of California at Los Angeles, Division of Digestive Diseases
Center for Neurobiology of Stress, CURE VAGLA HC
Bldg 115/CURE, 11303 Wilshire Blvd, Los Angeles, CA 90073 (USA)
Tel. +1 310 478 3711 ext 43790, Fax +1 310 794 2864, E-Mail firstname.lastname@example.org
Published online: March 04, 2010
Number of Print Pages : 13
Number of Figures : 6, Number of Tables : 0, Number of References : 92
Digestive Diseases (Clinical Reviews)
Vol. 27, No. Suppl. 1, Year 2009 (Cover Date: March 2010)
Journal Editor: Malfertheiner P. (Magdeburg)
ISSN: 0257-2753 (Print), eISSN: 1421-9875 (Online)
For additional information: http://www.karger.com/DDI