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Table of Contents
Vol. 212, No. 6, 1998
Issue release date: November – December
Section title: Original Paper · Travail original · Originalarbeit
Ophthalmologica 1998:212:410–414
(DOI:10.1159/000027378)

Detection of Vascular Endothelial Growth Factor and Tumor Necrosis Factor Alpha in Epiretinal Membranes of Proliferative Diabetic Retinopathy, Proliferative Vitreoretinopathy and Macular Pucker

Armstrong D.a · Augustin A.J.b · Spengler R.a · Al-Jada A.a · Nickola T.a · Grus F.b · Koch F.c
aDepartment of Clinical Laboratory Science and Pathology, University of Buffalo, N.Y., USA; bDepartment of Clinical Ophthalmology, University of Bonn, and cDepartment of Ophthalmology, University of Frankfurt, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Published online: September 23, 1998
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Purpose: To evaluate epiretinal membranes in proliferative eye disease for the presence of vascular endothelial growth factor (VEGF) and tumor necrosis factor α (TNF-α). Methods: Membranes were surgically removed from 66 patients with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR) and macular pucker (MP). Cytokine concentrations were determined by ELISA (VEGF) and bioassay (TNF-α). Results: VEGF was detected in all 66 membranes investigated. The highest VEGF values were found in patients with type I diabetes (mean = 5,994 pg/mg protein). In patients with type II diabetes, the values were at a mean of 1,242 pg/mg protein. When coagulation therapy was performed for longer than 3 months prior to surgery, VEGF was significantly (p < 0.05) reduced. Intermediate levels of VEGF were found in PVR membranes (mean = 1,417 pg/mg protein). The lowest activity was found in MP (mean = 216 pg/mg protein). In contrast, TNF-α was present in 16 PDR membranes, 9 PVR membranes and 8 MP membranes. Conclusion: The presence of VEGF in all membranes investigated indicates that this cytokine plays an important role in angiogenesis in ischemic retinal disease and in membrane growth in proliferative disorders.


Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Published online: September 23, 1998
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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