Original Paper · Travail original · Originalarbeit
Conjunctival Epithelium Expression of HLA-DR in Dry Eye PatientsTsubota K.a,b,c · Fujihara T.a · Saito K.b · Takeuchi T.d
aDepartment of Ophthalmology and bOral Health Science Center, Tokyo Dental College, Chiba, cDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, and dDepartment of 2nd Internal Medicine, Saitama Medical Center, Saitama Medical College, Saitama, Japan
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Purpose: To compare conjunctival epithelium expression of HLA-DR and ICAM-1 with tear dynamics and ocular surface parameters. Methods: Brush cytology and flow cytometry were used to quantitatively analyze HLA-DR and ICAM-1 expression in 28 dry eye patients. Results: HLA-DR was expressed in 66% of the conjunctival cells of dry eye patients. This expression correlates with that of ICAM-1, as well as with the Schirmer test results (p < 0.05). Conclusion: This study confirmed that dry eye consists not only of ocular surface desiccation, but also of upregulation of the HLA-DR and ICAM-1 molecule in the conjunctival epithelium, possibly resulting in increased inflammation.
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