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Table of Contents
Vol. 213, No. 6, 1999
Issue release date: November – December
Section title: Original Paper · Travail original · Originalarbeit
Ophthalmologica 1999;213:350–354
(DOI:10.1159/000027453)

Evaluation of the Analgesic Effect of 0.1% Indomethacin Solution on Corneal Abrasions

Patrone G. · Sacca S.C. · Macri A. · Rolando M.
Department of Neuroscience and Vision, Section of Ophthalmology R, University of Genoa, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Published online: November 02, 1999
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Purpose: The authors wished to verify the analgesic action of 0.1% indomethacin in a water-based solution on patients affected by traumatic corneal abrasions. Methods: 347 patients affected by traumatic corneal abrasions, having been randomly divided into 2 groups on the basis of the administration of indomethacin, were evaluated at 30 min, 12 h and 24 h after the initial treatment of the abrasion. The level of pain experienced was evaluated on a verbal pain scale and the healing time was evaluated relative to the dimension of the abrasion. Results: The pain level was initially overwhelming for both groups: p = 0.737; at successive check-ups it was possible to verify a reduction of the symptomatology, with a more pronounced decrease in pain in the group treated with indomethacin (p < 0.0001), which also demonstrated a lower sensitivity to pain in the case of larger lesions (p < 0.0001). There was no difference in the healing time between groups, and the reduction of pain is not correlated with corneal anesthesia and healing time. Conclusions: Our study highlighted the efficacy of indomethacin as a pain reducer for acute corneal pathology and suggested that the medication may act on the corneal nociceptors in a qualitative way.

© 1999 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper · Travail original · Originalarbeit

Published online: November 02, 1999
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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