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Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the LiteratureTeoh D.a · Freedman R.b · Soliman P.T.b
aDepartment of Gynecologic Oncology, Duke University, Durham, N.C., and bDepartment of Gynecologic Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, Tex., USA Corresponding Author
Assistant Prof. Pamela T. Soliman
Department of Gynecologic Oncology
University of Texas M.D. Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030 (USA)
Tel. +1 713 745 2352, Fax +1 713 792 7586, E-Mail firstname.lastname@example.org
A 30-year-old woman was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary in 1979. Following removal of the adnexal mass and complete surgical staging, she remained disease-free for 12 years. In 1991 she underwent a resection of a retroperitoneal mass, confirmed to be a recurrent GCT. Despite adjuvant radiation treatment at the time of recurrence, the patient presented five years later with abdominal pain, and was found to have a second recurrence. Over the next 10 years the patient had multiple recurrences and progressive disease despite surgical resection, cytotoxic, hormonal and targeted chemotherapy treatments. In conclusion, there is no standard management for recurrent GCT of the ovary. We review this patient’s treatment in the context of the current literature.
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