αB-Crystallin, which has homology with the small heat shock proteins, is the basic subunit of α-crystallin, a major component of the vertebrate eye lens. These crystallins have for a long time been thought to be absolutely lens specific. However, about a decade ago αB-crystallin has been detected extralenticularly in many tissues among which the central nervous system. Under pathological conditions the expression level of αB-crystallin frequently increases. For this reason it is considered to be a useful marker in a variety of neurodegenerative diseases. In this mini-review, a number of typical neurodegenerative disorders is dealt with in which αB-crystallin may play a role.
© 2000 S. Karger AG, Basel
Prof. Dr. Hans Bloemendal
Department of Biochemistry, University of Nijmegen
Trigon, Room 1.24, P.O. Box 9101
6252 EK Nijmegen (The Netherlands)
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 0, Number of References : 70
Ophthalmologica (International Journal of Ophthalmology)
Founded 1899 as ‘Zeitschrift für Augenheilkunde’ by H. Kuhnt and J. von Michel
Vol. 214, No. 1, Year 2000 (Cover Date: January-February 2000)
Journal Editor: Ch. Ohrloff, Frankfurt a.M.
ISSN: 0030–3755 (print), 1423–0267 (Online)
For additional information: http://www.karger.com/journals/oph
Article / Publication Details
Published online: 2/3/2000
Issue release date: January–February 2000
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: http://www.karger.com/OPH
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