Effective Treatment with Topical Cyclosporin A of a Patient with Cogan SyndromeShimura M. · Yasuda K. · Fuse N. · Nakazawa M. · Tamai M.
Department of Ophthalmology, School of Medicine, Tohoku University, Sendai, Miyagi, Japan
The purpose of this report is to describe the effective treatment of severe anterior segment inflammation due to Cogan syndrome through the use of topical administration of cyclosporin A. A 47-year-old female patient had been experiencing headaches and difficulties with her vision. Subsequent examination revealed the sudden onset of bilateral conjunctival injection and swelling of bilateral auricles. Despite the multiple treatment (systemic and topical corticosteroid and antibiotic therapy), necrotizing scleritis had appeared bilaterally and the scleral wall was thinning. Topical administration of 1% cyclosporin A was applied to both eyes 4 times a day. After 2 months of this therapy, the epithelial tissue covered the necrotizing tissue and her symptom of ocular pain was relieved and her corrected visual acuity was improved. This is the first case exhibiting that topical cyclosporin A is an effective treatment for severe anterior segment inflammation associated with Cogan syndrome.
Masahiko Shimura, MD, PhD
Department of Ophthalmology
School of Medicine, Tohoku University
1-1 Seiryo, Aoba, Sendai 980-8574 (Japan)
Tel. +81 22 717 7294, Fax +81 22 717 7298, E-Mail firstname.lastname@example.org
Received: Received: November 8, 1999
Accepted after revision: March 8, 2000
Number of Print Pages : 4
Number of Figures : 3, Number of Tables : 0, Number of References : 12
Ophthalmologica (International Journal of Ophthalmology)
Founded 1899 as ‘Zeitschrift für Augenheilkunde’ by H. Kuhnt and J. von Michel
Vol. 214, No. 6, Year 2000 (Cover Date: November-December 2000)
Journal Editor: Ch. Ohrloff, Frankfurt a.M.
ISSN: 0030–3755 (print), 1423–0267 (Online)
For additional information: http://www.karger.com/journals/oph