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Vol. 25, No. 2-3, 2010
Issue release date: 2010
Section title: Original Paper
Cell Physiol Biochem 2010;25:263–270

External Qi of Yan Xin Qigong Induces Apoptosis and Inhibits Migration and Invasion of Estrogen-Independent Breast Cancer Cells Through Suppression of Akt/NF-ĸB Signaling

Yan X.1,2 · Shen H.2 · Jiang H.3 · Hu D.4 · Zhang C.5 · Wang J.2 · Wu X.3,4
1Chongqing Institute of Traditional Chinese Medicine, Chongqing,2New Medical Science Research Institute, New York,3Brigham and Women’s Hospital and Harvard Medical School, Boston,4Dana-Farber Cancer Institute and Harvard Medical School, Boston,5McMaster University, Hamilton

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The antitumor effects of external Qi of Yan Xin Qigong (YXQ-EQ) have been widely described over the past three decades. To gain a better understanding of the mechanisms underlying YXQ-EQ’s antitumor effects, in the present study we investigated its effects on growth, migration, invasion and apoptosis of breast cancer cells and the underlying molecular mechanisms. We show that YXQ-EQ treatment caused a time-dependent reduction in viability, blocked clonogenic growth and induced apoptosis in estrogen-independent breast cancer MDA-MB-231 cells. Furthermore, YXQ-EQ treatment blocked migration and invasion of MDA-MB-231 cells. Biochemically, YXQ-EQ treatment markedly inhibited constitutive and EGF-induced Akt phosphorylation. YXQ-EQ also substantially repressed NF-ĸB activity, resulting in decreased expression of anti-apoptotic Bcl-2, Bcl-XL, XIAP and survivin proteins. These findings suggest that YXQ-EQ may induce apoptosis and inhibition of migration and invasion of MDA-MB-231 cells through the repression of Akt/NF-ĸB signaling.

© 2010 S. Karger AG, Basel


Author Contacts

Xinqi Wu
Dana-Farber Cancer Institute and Harvard Medical School
44 Binney Street, Boston, MA 02115 (USA)
Tel. +1 617 582 8303, Fax: +1 617 582 7992


Article Information

Accepted: October 13, 2009
Published online: January 12, 2010
Number of Print Pages : 8


Publication Details

Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry and Pharmacology)

Vol. 25, No. 2-3, Year 2010 (Cover Date: 2010)

Journal Editor: F. Lang, Tübingen
ISSN: 1015–8987 (Print), eISSN: 1421–9778 (Online)

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Article / Publication Details

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Abstract of Original Paper

Accepted: 10/13/2009
Published online: 1/12/2010
Issue release date: 2010

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

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