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Vol. 34, No. 3, 2010
Issue release date: April 2010
Section title: Original Paper
Neuroepidemiology 2010;34:163–170
(DOI:10.1159/000279333)

A Prospective Study of SCA3 Gait Ataxia Described through a Markovian Method

Camey S. · Jardim L.B. · Kieling C. · Saute J.A.M. · Vigo Á.
Departments of aStatistics and bInternal Medicine, Universidade Federal do Rio Grande do Sul, and Departments of cMedical Genetics, dPsychiatry and eNeurology Services, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/4/2009
Accepted: 12/3/2009
Published online: 2/2/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: Studies on the natural history of rare, chronic diseases like spinocerebellar ataxia 3 (SCA3) are hard to be done, since patients enter the study with variable disease durations and are followed up at irregular intervals. Aims: Our purpose was to use all the available data to describe the progression of gait ataxia in a long-term cohort of patients with SCA3 through a markovian method. Materials and Methods: SCA3 patients were recruited between 1998 and 2005 and were invited to annual neurological follow-ups until 2007. Gait ataxia was described through a mean score graph and a mean trajectory graph. Results: We followed up 105 patients; at baseline, the mean age and disease duration were, 40.5 (SD = 12.6) and 7.7 (SD = 5.8) years, respectively. The mean time to reach stages 1, 2, 3 and 4 of gait ataxia were 3, 5.4, 10.8 and 19.4 years of disease duration. The mean score graph was unsmooth, showing several unlikely ups and downs. The mean trajectory graph produced a continuous curve. Conclusion: The markovian method described the natural history of gait ataxia without any a posteriori adjustment of data and allowed statistical comparisons between subgroups. This method will be useful in future clinical trials in this and in other chronic degenerative diseases.


  

Author Contacts

Laura Bannach Jardim, MD, PhD
Medical Genetics Service, Hospital de Clínicas de Porto Alegre
Rua Ramiro Barcelos, 2350
Porto Alegre 90035-903 (Brazil)
Tel. +55 51 3359 8011, Fax +55 51 3359 8010, E-Mail ljardim@hcpa.ufrgs.br

  

Article Information

Received: June 4, 2009
Accepted: December 3, 2009
Published online: February 2, 2010
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 4, Number of References : 17

  

Publication Details

Neuroepidemiology

Vol. 34, No. 3, Year 2010 (Cover Date: April 2010)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251-5350 (Print), eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/4/2009
Accepted: 12/3/2009
Published online: 2/2/2010

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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