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Vol. 34, No. 3, 2010
Issue release date: April 2010
Section title: Review
Neuroepidemiology 2010;34:171–183
(DOI:10.1159/000279334)

The Incidence of Myasthenia Gravis: A Systematic Literature Review

McGrogan A. · Sneddon S. · de Vries C.S.
aDepartment of Pharmacy and Pharmacology, University of Bath, Bath, and bDepartment of Pharmacoepidemiology, Postgraduate Medical School, University of Surrey, Guildford, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/4/2009
Accepted: 12/7/2009
Published online: 2/2/2010

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Background: A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken. Methods: All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data. Results: Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis. Conclusions: The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0–19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed.


  

Author Contacts

Dr. Anita McGrogan
Department of Pharmacy and Pharmacology
University of Bath
Bath BA2 7AY (UK)
Tel. +44 1225 384 142, Fax +44 1225 386 114, E-Mail a.mcgrogan@bath.ac.uk

  

Article Information

Received: August 4, 2009
Accepted: December 7, 2009
Published online: February 2, 2010
Number of Print Pages : 13
Number of Figures : 2, Number of Tables : 2, Number of References : 45

  

Publication Details

Neuroepidemiology

Vol. 34, No. 3, Year 2010 (Cover Date: April 2010)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251-5350 (Print), eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 8/4/2009
Accepted: 12/7/2009
Published online: 2/2/2010

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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