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Table of Contents
Vol. 77, No. 6, 2009
Issue release date: February 2010
Section title: Review
Oncology 2009;77:400–410
(DOI:10.1159/000279388)

EGFR Signaling and Drug Discovery

Lurje G.a · Lenz H.-J.b, c
aDepartment of Visceral- and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland; bDivision of Medical Oncology and cDepartment of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: March 31, 2009
Accepted: April 09, 2009
Published online: February 02, 2010
Issue release date: February 2010

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Dysregulation of human epidermal growth factor receptor (ErbB/HER) pathways by over-expression or constitutive activation can promote tumor processes including angiogenesis and metastasis and is associated with poor prognosis in many human malignancies. In addition to cancer, ErbB signaling has also been implicated in cardiovascular and neurodegenerative diseases. Conversely, inhibition of ErbB pathways with targeted agents, such as monoclonal antibodies (MoAbs) or tyrosine kinase inhibitors (TKIs), blocks cell cycle progression, inhibits the production of pro-angiogenic factors and induces apoptosis in numerous in vitro and xenograft models. Accordingly, the ErbB receptor family with their most prominent members EGFR and HER-2 represents validated targets for anti-cancer therapy, and anti-ErbB MoAbs (cetuximab, panitumumab, and trastuzumab) and TKIs (gefitinib, erlotinib, and lapatinib) have now been approved for the treatment of advanced colorectal cancer, squamous cell carcinoma of the head and neck, advanced non-small-cell lung cancer, as well as pancreatic and breast cancer. Although results have been encouraging, more work remains to be done.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: March 31, 2009
Accepted: April 09, 2009
Published online: February 02, 2010
Issue release date: February 2010

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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