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Vol. 67, No. 4, 1999
Issue release date: July–August 1999 (January 2000)
Section title: Original Paper
Pathobiology 1999;67:180–185
(DOI:10.1159/000028070)

Role of Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor in MiceBear ing a Highly Invasive and Metastatic Mammary Carcinoma

Gabri M.R.a · Menna P.L.a · Scursoni A.M.b · Gomez D.E.a · Alonso D.F.a
aLaboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, Bernal, and bPathology Service, ‘Evita Pueblo’ General Hospital, Berazategui, Buenos Aires, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/28/2000
Issue release date: July–August 1999 (January 2000)

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

We have examined the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in tumor-bearing BALB/c mice using the syngeneic F3II mammary carcinoma. In the present model, progression of subcutaneous tumors induced massive myelopoiesis in bone marrow and spleen due to GM-CSF secretion by tumor cells. In vitro, the addition of recombinant mouse GM-CSF (5– 25 ng/ml) caused a significant increase in F3II cell growth, either in the presence or absence of serum. Zymographic analysis of conditioned media from F3II monolayers showed that GM-CSF exerted a dose-dependent enhancement in the metalloproteinases MMP-9 (105 kD) and MMP-2 (70 kD), key enzymes in mammary tumor cell invasion. Our data suggest that ectopic GM-CSF production stimulates myelopoiesis and may also play an important role in tumor progression and metastasis formation.

© 2000 S. Karger AG, Basel


  

Author Contacts

Dr. Daniel F. Alonso
Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes
R. Sáenz Pena 180, Bernal, Buenos Aires 1876 (Argentina)
Tel. +54 11 4365 710, ext. 171, Fax +54 11 4365 7132
E-Mail dfalonso@unq.edu.ar

  

Article Information

Received: Received: May 10, 1999
Accepted: July 29, 1999
Number of Print Pages : 6
Number of Figures : 5, Number of Tables : 0, Number of References : 28

  

Publication Details

Pathobiology (Journal of Immunopathology, Molecular and Cellular Biology)
Founded 1938 as ‘Schweizerische Zeitschrift für allgemeine Pathologie und Bakteriologie’ by A. v. Albertini, A. Grumbach and H. Mooser

Vol. 67, No. 4, Year 1999 (Cover Date: July-August 1999 (Released January 2000))

Journal Editor: Ch. Wittekind, Leipzig
ISSN: 1015–2008 (print), 1423–0291 (Online)

For additional information:http://www.karger.com/journals/pat


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/28/2000
Issue release date: July–August 1999 (January 2000)

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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