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Vol. 43, No. 1, 1988
Issue release date: 1988
Section title: Original Paper
Urol Int 1988;43:11–15
(DOI:10.1159/000281294)

Norfenefrine in the Treatment of Female Stress Incontinence

A Double-Blind Controlled Trial

Lose G. · Rix P. · Diernæs E. · Alexander N.
Department of Obstetrics and Gynaecology, Kolding Hospital, Kolding, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/29/1987
Accepted: 8/13/1987
Published online: 1/29/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Forty-four consecutive patients with genuine stress incontinence were treated with norfenefrine 15–30 mg t.i.d. in a 6-week, double-blind and parallel, placebo-controlled study. Subjectively, 52% were improved and 26% became continent during norfenefrine treatment. Objectively (stress test), 30% became continent and the maximum urethral closure pressure increased 10% which was statistically significant. These results, however, were not statistically different from those of placebo treatment. Simultaneously, subjective and objective improvement was seen more often in patients given norfenefrine compared to placebo (p < 0.1). In patients with most severe incontinence according to urodynamic criteria the effect of norfenefrine was statistically significantly better than placebo. A low incidence of side effects was observed and no differences between norfenefrine and placebo were found. It is concluded that norfenefrine may be of value in the treatment of female stress incontinence.


  

Author Contacts

G. Lose, MD, Department of Surgery D, Section of Urology, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen·(Denmark)

  

Article Information

Received: June 29, 1987
Accepted: August 13, 1987
Published online: January 29, 2010
Number of Print Pages : 5

  

Publication Details

Urologia Internationalis

Vol. 43, No. 1, Year 1988 (Cover Date: 1988)

Journal Editor: Wirth M.P. (Dresden), Porena M. (Perugia), Hakenberg O.W. (Rostock), Castro-Diaz D. (Santa Cruz de Tenerife)
ISSN: 0042-1138 (Print), eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/29/1987
Accepted: 8/13/1987
Published online: 1/29/2010

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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