Animal Models of Non-Alcoholic Steatohepatitis: Of Mice and ManSchattenberg J.M. · Galle P.R.
I. Medizinische Klinik, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz, Germany
The epidemic occurrence of obesity has led to a rapid increase in the incidence of non-alcoholic fatty liver disease (NAFLD) in industrial countries. The disease spectrum includes hepatic steatosis, lobular inflammation with steatohepatitis (NASH) and varying degrees of liver fibrosis, which can progress to cirrhosis. Hepatocellular carcinoma can develop in patients with NASH, even in the absence of cirrhosis. The majority of patients with primary NASH exhibit risk factors that define the metabolic syndrome including insulin resistance and visceral obesity. However, only a minority of patients with NAFLD progress to end-stage liver disease and, so far, predictors to identify these patients are not available. The course of disease progression appears to be slow and develops progressively over years, modulated by genetic susceptibility, nutritional misbehavior and environmental factors. Although risk factors have been identified in epidemiological studies, little is known about disease initiation and progression. This review summarizes the existing animal models of NAFLD, focusing on genetic and dietary models, and discusses their applicability in studying signaling events involved in steatohepatitis. Despite the shortcomings inherent to all experimental models, research in this field has helped to identify potential therapeutic targets and, thus, contributed significantly to our understanding of this disease. The validation and search for new in vivo and in vitro models will propagate the understanding of NASH and help clinicians to develop new treatment modalities.
© 2010 S. Karger AG, Basel
J.M. Schattenberg, MD
I. Medizinische Klinik, Universitätsmedizin der Johannes Gutenberg-Universität
DE–55101 Mainz (Germany)
Tel. +49 6131 176 074, Fax +49 6131 1747 7282, E-Mail firstname.lastname@example.org
Published online: May 07, 2010
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 1, Number of References : 71
Digestive Diseases (Clinical Reviews)
Vol. 28, No. 1, Year 2010 (Cover Date: May 2010)
Journal Editor: Malfertheiner P. (Magdeburg)
ISSN: 0257-2753 (Print), eISSN: 1421-9875 (Online)
For additional information: http://www.karger.com/DDI