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Vol. 7, No. 1-3, 2010
Issue release date: April 2010
Section title: Biology of Neurodegeneration
Neurodegenerative Dis 2010;7:13–15
(DOI:10.1159/000283476)

Tau Kinase I Overexpression Induces Dentate Gyrus Degeneration

Avila J.a, b · Gómez de Barreda E.a · Engel T.d · Pérez M.a, c · Martín-Maestro P.a · Fuster-Matanzo A.a · Goñi-Oliver P.a, b · Lucas J.J.a, b · Hernández F.a
aCentro de Biología Molecular Severo Ochoa (CSIC-UAM), bDepartamento de Neurociencias y Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), cDepartamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain; dDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Biology of Neurodegeneration

Published online: 2/13/2010
Issue release date: April 2010

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Familial Alzheimer gene mutations result in a signaling mechanism that converges, downstream, in the activation of GSK3 activity. We have generated a GSK3 transgenic mouse model to study the consequences of GSK3 activation. In this model, dentate gyrus is degenerated in a process in which phosphorylated tau can be involved.

© 2010 S. Karger AG, Basel


  

Author Contacts

Jesús Avila
Centro de Biología Molecular Severo Ochoa (CSIC-UAM)
C/ Nicolás Cabrera 1, Universidad Autónoma de Madrid, Campus Cantoblanco
ES–28049 Madrid (Spain)
Tel. +34 91 196 44 20, Fax +34 91 196 45 64, E-Mail javila@cbm.uam.es

  

Article Information

Published online: February 13, 2010
Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 16

  

Publication Details

Neurodegenerative Diseases

Vol. 7, No. 1-3, Year 2010 (Cover Date: April 2010)

Journal Editor: Nitsch R.M. (Zürich), Hock C. (Zürich)
ISSN: 1660-2854 (Print), eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Biology of Neurodegeneration

Published online: 2/13/2010
Issue release date: April 2010

Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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