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Vol. 98, No. 3, 2010
Issue release date: September 2010
Section title: Original Paper
Neonatology 2010;98:232–237
(DOI:10.1159/000283946)

Effect of Indomethacin Infused over 30 Minutes on Cerebral Fractional Tissue Oxygen Extraction in Preterm Newborns with a Patent Ductus Arteriosus

Keating P. · Verhagen E. · van Hoften J. · ter Horst H. · Bos A.F.
Division of Neonatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2009
Accepted: 11/4/2009
Published online: 4/13/2010

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: A significant patent ductus arteriosus (PDA) is a common finding in the first days of life and, if persistent, is associated with an increased morbidity and mortality in the preterm newborn. Objectives: Our aim was to investigate, using near-infrared spectroscopy, the effect of indomethacin on the fractional tissue (cerebral) oxygen extraction (FTcOE) in a group of preterm newborns undergoing medical treatment for a PDA. Methods: This is a prospective, observational study. A cohort of 18 preterm newborns (<32 weeks) undergoing treatment for a PDA with indomethacin were monitored continuously for mean arterial blood pressure, arterial oxygen saturation (SpO2) and regional cerebral oxygen saturation (rcSO2). Measurements were started 1 h before and continued for 4 h after the first indomethacin dose. A final measurement (1 h) was made within 24 h of completing the full course. FTcOE = [SpO2 – rcSO2]/SpO2 was then calculated. To analyze the data, we chose to average the measurements over 1-hour periods. Results: There was a significant increase in the FTcOE (0.06, 95% CI 0.04–0.09, p < 0.001) noticeable within the 1st hour after the start of indomethacin administration, which peaked in the 2nd hour (FTcOE increased by 0.08, 95% CI 0.04–0.11, p < 0.001) and lasted for the full 4-hour period measured. Conclusion: Indomethacin, infused over 30 min, significantly increased the FTcOE in the preterm newborn, the effect lasting at least 4 h. This may represent a protective response to the indomethacin-induced reduction in cerebral blood flow demonstrated by others and warrants further investigation.


  

Author Contacts

Paul Keating
Division of Neonatology, Department of Paediatrics
University Medical Centre Groningen, PO Box 30001
NL–9700 RB Groningen (The Netherlands)
Tel. +31 50 361 4215, Fax +31 50 361 4235, E-Mail keatingp69@gmail.com

  

Article Information

Received: March 3, 2009
Accepted after revision: November 4, 2009
Published online: April 13, 2010
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 18

  

Publication Details

Neonatology (Fetal and Neonatal Research)

Vol. 98, No. 3, Year 2010 (Cover Date: September 2010)

Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661-7800 (Print), eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/3/2009
Accepted: 11/4/2009
Published online: 4/13/2010

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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