Journal Mobile Options
Table of Contents
Vol. 61, No. 3, 2000
Issue release date: September 2000
Section title: Paper
Pharmacology 2000;61:192–198
(DOI:10.1159/000028400)

Polymorphisms of Human Aldehyde Dehydrogenases

Consequences for Drug Metabolism and Disease

Vasiliou V. · Pappa A.
Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colo., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/13/2000

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Aldehyde dehydrogenases (ALDHs), a superfamily of NAD(P)+-dependent enzymes with similar primary structures, catalyze the oxidation of a wide spectrum of endogenous and exogenous aliphatic and aromatic aldehydes. Thus far, 16 ALDH genes with distinct chromosomal locations have been identified in the human genome. Polymorphism in ALDH2 is associated with altered acetaldehyde metabolism, decreased risk of alcoholism and increased risk of ethanol-induced cancers. Polymorphisms in ALDH3A2, ALDH4A1, ALDH5A1 and ALDH6A1 are associated with metabolic diseases generally characterized by neurologic complications. Mutations in ALDH3A2 cause loss of enzymatic activity and are the molecular basis of Sjögren-Larsson syndrome. Mutations in ALDH4A1 are associated with type II hyperprolinemia. Deficiency in ALDH5A1 causes 4-hydroxybutyric aciduria. Lack of ALDH6A1 appears to be associated with developmental delay. Allelic variants of the ALDH1A1, ALDH1B1, ALDH3A1 and ALDH9A1 genes have also been observed but not yet characterized. This review describes consequences of ALDH polymorphisms with respect to drug metabolism and disease.


  

Author Contacts

V. Vasiliou, MD
Department of Pharmaceutical Sciences
University of Colorado Health Sciences Center
4200 East Ninth Avenue, Denver, CO 80262 (USA)
Tel. +1 303 315 6153, Fax +1 303 315 6281, E-Mail vasilis.vasiliou@uchsc.edu

  

Article Information

Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 1, Number of References : 48

  

Publication Details

Pharmacology (International Journal of Experimental and Clinical Pharmacology)
Founded 1959 as ‘Medicina Experimentalis’, continued 1965–1967 as ‘Medicina et Pharmacologia Experimentalis’; Founder: R. Domenjoz (1959–1977); Successors: B.B. Brodie (1968–1977); K. Lederis (1973–1985)

Vol. 61, No. 3, Year 2000 (Cover Date: Released September 2000)

Journal Editor: J. Donnerer, Graz; E.S. Vesell, Hershey, Pa.; T. Watanabe, Sendai
ISSN: 0031–7012 (print), 1423–0313 (Online)

For additional information: http://www.karger.com/journals/pha


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/13/2000

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.