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Vol. 66, No. 6, 1997
Issue release date: 1997
Section title: Special Article
Psychother Psychosom 1997;66:286–292
(DOI:10.1159/000289150)

Depression in Multiple Sclerosis

Patten S.B.a · Metz L.M.b
aAlberta Heritage Foundation for Medical Research, Departments of Community Health Sciences and Psychiatry, and bThe University of Calgary Multiple Sclerosis Clinic, Department of Clinical Neuroscience, The University of Calgary, Canada

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Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: 2/18/2010
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS

Abstract

Background: An association between multiple sclerosis (MS) and depression has been recognized for several decades and has attracted considerable attention in research. However, there are considerable gaps in the current state of knowledge. In this review, the literature concerned with: (1) the burden of depression in MS; (2) the etiology of depression in MS, and (3) the treatment of depression in MS are critically examined. Method: The literature review utilized Medline (1966–1996), and was supplemented by citations extracted from the papers originally uncovered. Results: Numerous studies have identified elevated depressive symptom scores in MS patients relative to nonclinical and (some) clinical control groups. Furthermore, studies of depressive disorders have clearly documented elevated prevalence rates in MS samples. The literature does not identify any specific pattern of neurological involvement as being consistently associated with depressive symptoms or disorders. Psychosocial risk factors contribute to the etiology of depression in MS, but the relative importance of various risk factors is yet to be determined. A single randomized controlled clinical trial, and additional anecdotal evidence, suggests that antidepressant pharmacotherapy is effective for depressive disorders in MS. Conclusions: Future epidemiological studies should not restrict their evaluation of risk factors to those specific factors that are closely related to the disease process. In particular, future researchers should resist the temptation to focus too exclusively on neuropathology. Biological, psychological and social risk factors are all potentially important. Additional empirical efforts to refine the various treatment approaches would be a welcome addition to this literature.

© 1997 S. Karger AG, Basel


  

Author Contacts

Scott B. Patten, MD, FRCPC, PhD, Department of Community Health Sciences, The University of Calgary, 3330 Hospital Drive N.W., Calgary, Alta. T2N 4N1 (Canada)

  

Article Information

Published online: February 18, 2010
Number of Print Pages : 7

  

Publication Details

Psychotherapy and Psychosomatics

Vol. 66, No. 6, Year 1997 (Cover Date: 1997)

Journal Editor: Fava G.A. (Bologna)
ISSN: 0033-3190 (Print), eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS


Article / Publication Details

First-Page Preview
Abstract of Special Article

Published online: 2/18/2010
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: http://www.karger.com/PPS


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