Introduction: The goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI). Methods: Heart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury. Results: There were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049). Conclusion: CBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.
Susan R. Durham, MD
University of Pennsylvania School of Medicine
Department of Neurosurgery
3400 Spruce Street, Philadelphia, PA 19104 (USA)
Tel. +1 215 662 3487, Fax +1 215 349 5108, E-Mail firstname.lastname@example.org
Received: Received: May 10, 2000
Accepted: July 21, 2000
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 23
Founded 1985 by E.B. Hendrick and D.H. Reigel; Editor-in-Chief 1992–1996: F.J. Epstein
Official Journal of the American Society of Pediatric Neurosurgeons (ASPN)
Vol. 33, No. 2, Year 2000 (Cover Date: August 2000)
Journal Editor: D.G. McLone, Chicago, Ill.
ISSN: 1016–2291 (print), 1423–0305 (Online)
For additional information: http://www.karger.com/journals/pne
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