Introduction: The goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI). Methods: Heart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury. Results: There were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049). Conclusion: CBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.
© 2000 S. Karger AG, Basel
Susan R. Durham, MD
University of Pennsylvania School of Medicine
Department of Neurosurgery
3400 Spruce Street, Philadelphia, PA 19104 (USA)
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Received: Received: May 10, 2000
Accepted: July 21, 2000
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 23
Founded 1985 by E.B. Hendrick and D.H. Reigel; Editor-in-Chief 1992–1996: F.J. Epstein
Official Journal of the American Society of Pediatric Neurosurgeons (ASPN)
Vol. 33, No. 2, Year 2000 (Cover Date: August 2000)
Journal Editor: D.G. McLone, Chicago, Ill.
ISSN: 1016–2291 (print), 1423–0305 (Online)
For additional information: http://www.karger.com/journals/pne
Article / Publication Details
Published online: 10/27/2000
Issue release date: August 2000
Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2
ISSN: 1016-2291 (Print)
eISSN: 1423-0305 (Online)
For additional information: http://www.karger.com/PNE
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