Different Coexisting Endometrial Histological Features in Asymptomatic Postmenopausal Breast Cancer Patients Treated with TamoxifenCohen I. · Altaras M.M. · Shapira J. · Tepper R. · Cordoba M. · Figer A. · Zalel Y. · Dror Y. · Beyth Y.
aDepartment of Obstetrics and Gynecology, bGynecological Oncology, cMedical Oncology Units, and dDepartment of Pathology, Sapir Medical Center, Kfar Saba; eDepartment of Oncology, Beilinson Medical Center, Petach Tikva; Affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
In an attempt to assess the hypothesis that different endometrial sites may respond differently to tamoxifen exposure in postmenopausal women, hysteroscopic selected endometrial histology was investigated in 175 postmenopausal breast cancer patients who received continuous treatment with tamoxifen, and in 27 similar patients not treated with tamoxifen who served as controls. In the tamoxifen-treated patients 14 (8.0%) developed endometrial polyps. Of 14 patients, 8 (57.2%) each displayed atrophic endometrium in the same histologic specimen, 5 (35.7%) each had coexisting simple hyperplasia, and 1 (7.1%) other had complex hyperplasia. Another 21 (12.0%) developed simple or complex hyperplasia. The endometrial hyperplasia coexisted with atrophic endometrium in all these patients. All these lesions were selectively identified by hysteroscopic examination prior to the endometrial biopsy. In the control group 3 (11.0%) had simple hyperplasia and 2 (7.4%) had endometrial polyps. The above results support the hypothesis that the endometrium of postmenopausal breast cancer patients on tamoxifen treatment may possess different responses to tamoxifen exposure.
Ilan Cohen, MD, Department of Obstetrics and Gynecology, Sapir Medical Center, Kfar Saba, 44281 (Israel), Tel. +972 9 90 05 61 Fax +972 9 910596
Received: November 14, 1995
Accepted after revision: June 24, 1996
Published online: February 26, 2010
Number of Print Pages : 4
Gynecologic and Obstetric Investigation
Vol. 43, No. 1, Year 1997 (Cover Date: 1997)
Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)
For additional information: http://www.karger.com/GOI