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Vol. 43, No. 4, 1997
Issue release date: 1997
Section title: Original Paper
Gynecol Obstet Invest 1997;43:225–231
(DOI:10.1159/000291862)

Value of the Maternal Interleukin 6 Level for Determination of Histologic Chorioamnionitis in Preterm Delivery

Maeda K.a,d · Matsuzaki N.c · Fuke S.a · Mitsuda N.a · Shimoya K.c · Nakayama M.b · Suehara N.a · Aono T.d
Departments of aObstetrics and bPathology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka; cDepartment of Obstetrics and Gynecology, Osaka University Medical School, Osaka; dDepartment of Obstetrics and Gynecology, University of Tokushima School of Medicine, Tokushima, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/1/1996
Accepted: 11/6/1996
Published online: 2/26/2010
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

The present study examined whether maternal serum cytokine levels are useful for the diagnosis of histologic chorioamnionitis. The blood samples of 29 women who delivered preterm between 22 and 34 weeks of gestation were collected at delivery, and placentas were histopathologically examined for chorioamnionitis. The interleukin (IL) 6 titer was higher in 18 mothers with histologic chorioamnionitis (median 12.0 pg/ml, range 4.9-63.5 pg/ml) than that in 11 mothers without histologic chorioamnionitis (median 3.5 pg/ml, range 1.7–14.9 pg/ml; p < 0.0001). The C-reactive protein (CRP) titer also differed significantly between these two groups (chorioamnionitis group: median 5.2 mg/dl, range 0.1–12.3 mg/dl; no chorioamnionitis group: median 0.2 mg/dl, range 0.1–0.5 mg/dl; p = 0.0001). The IL-6 titer showed better clinical diagnostic indices and a higher odds ratio (9.78, 95% confidence interval 1.50-63.82) than did CRP (3.26, 95% confidence interval 1.22–8.67). The levels of IL-8, monocyte chemotactic and activating factor, and soluble IL·6 receptor did not differ between the two groups. These data suggest that the level of maternal serum IL·6 is more useful than other markers, including CRP, for the identification of women at risk of impending preterm labor with histologic chorioamnionitis.

© 1997 S. Karger AG, Basel


  

Author Contacts

K. Maeda, MD, Department of Obstetrics and Gynecology, University of Tokushima School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770 (Japan), Tel.+81 88631 3111, Fax+81 886312630

  

Article Information

Received: February 1, 1996
Accepted after revision: November 6, 1996
Published online: February 26, 2010
Number of Print Pages : 7

  

Publication Details

Gynecologic and Obstetric Investigation

Vol. 43, No. 4, Year 1997 (Cover Date: 1997)

Journal Editor: D'Hooghe T. (Leuven)
ISSN: 0378-7346 (Print), eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/1/1996
Accepted: 11/6/1996
Published online: 2/26/2010
Issue release date: 1997

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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